Evidence map›Paper›PMID 34997087›Full record

ArticleScientific reports2022

Association between vitamin D3 levels and insulin resistance: a large sample cross-sectional study.

Zixin Xu, Rongpeng Gong, Gang Luo, Mingxiang Wang, Da Li, Yue Chen, Xiaofang Shen, Xiaoxing Wei, Niran Feng, Shuangquan Wang

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 1 country.

Zixin Xu *Shaanxi University of Chinese Medicine, Xi'an, 712046, Shaanxi, People's Republic of China.
Rongpeng Gong *Medical College of Qinghai University, Xining, 810016, Qinghai, People's Republic of China.
Gang Luo *College of Eco-Environmental Engineering, Qinghai University, Xining, 810016, Qinghai, People's Republic of China.
Mingxiang Wang *Medical College of Qinghai University, Xining, 810016, Qinghai, People's Republic of China.
Da LiXi'an Chang'an District Hospital of Traditional Chinese Medicine, Xi'an, 710100, Shaanxi, People's Republic of China.
Yue ChenDepartment of Clinical Medicine, School of the First Clinical Medicine, Anhui Medical University, No. 81 Meishan Road, Hefei, 230032, Anhui, People's Republic of China.
Xiaofang ShenDepartment of Nephrology, Aerospace Center Hospital, 15 Yuquan Road, Beijing, 100049, People's Republic of China.
Xiaoxing WeiMedical College of Qinghai University, Xining, 810016, Qinghai, People's Republic of China.
Niran FengTianjin University of Chinese Medicine, Tianjin, 301617, People's Republic of China.
Shuangquan WangShaanxi University of Chinese Medicine, Xi'an, 712046, Shaanxi, People's Republic of China. 13572970680@139.com.
Qinghai University · CNAerospace Center Hospital · CNAnhui Medical University · CNChina XD Group (China) · CNShaanxi Provincial Hospital of Traditional Chinese Medicine · CNShaanxi University of Chinese Medicine · CNTianjin University of Traditional Chinese Medicine · CN

Funding

Xiaoxing Wei 81860370
6 · The paper itself

Abstract

Previous studies have shown that vitamin D3 may be a potential factor in insulin resistance, but the relationship between vitamin D3 and insulin resistance still remains controversial. At present, more research is needed to explore the relationship between vitamin D3 and insulin resistance. The samples from 2009 to 2018 in NHANES database were analyzed to Investigate the relationship and the potential mechanism. We performed a cross-sectional study of five periods in the NHANES database. Finally, 9298 participants were selected through strict inclusion and exclusion criteria, Multivariate logistic regression analysis and curve fitting were conducted to explore the relationship between vitamin D3 level and insulin resistance. Moreover, subgroup analysis was used to further prove the association. The results revealed that there was a strong association between vitamin D3 and insulin resistance (OR 0.82, 95% CI 0.72-0.93). However, subgroup analyses indicated that this correlation varied between individuals and races. There was a negative correlation between vitamin D3 level and insulin resistance, which provides a new proof for exploring the influencing factors of insulin resistance. More well-designed studies are still needed to further elaborate on these associations.

Indexed as

Insulin ResistanceAdultAgedBiomarkersBlood GlucoseCholecalciferolCross-Sectional StudiesDatabases, FactualGlycated HemoglobinHumansInsulinMiddle AgedNutrition SurveysRace FactorsRisk AssessmentRisk FactorsBiomarkersBlood GlucoseCholecalciferolGlycated Hemoglobinhemoglobin A1c protein, humanInsulin

Identifiers

PMID34997087
PMCPMC8741779
OpenAlexW4205618158

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.