ArticleScientific reports2022
A scoring system combining clinical, radiological, and histopathological examinations for differential diagnosis between lipoma and atypical lipomatous tumor/well-differentiated liposarcoma.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Diagnostic accuracy of CT and MR features for detecting atypical lipomatous tumors and malignant liposarcomas: a systematic review and meta-analysis.European radiology · 2023Pooled it
- Evaluation of Magnetic Resonance Imaging Features to Distinguish Lipomas from Atypical Lipomatous Tumours in the Extremities and Back.Diagnostics (Basel, Switzerland) · 2026Article
- Clinical Course and Dedifferentiation of Atypical Lipomatous Tumors: A Retrospective Analysis of Surveillance and Surgical Management.Annals of surgical oncology · 2026Article
- What are the surgical and oncologic outcomes, as well as the complications, associated with pre-operative radiotherapy in patients with low-grade soft-tissue sarcoma?International journal of clinical oncology · 2026Article
- Multimodal Imaging of Oncocytic Lipoadenoma Arising from the Parotid Deep Lobe with Medial Extension into the Parapharyngeal Space: A Case Report with Histopathologic Findings and Literature Review.Diagnostics (Basel, Switzerland) · 2026Article
- Giant Cervical Lipoma: The First Documented Case Report From Ethiopia.Clinical case reports · 2026Article
- Intratendinous Lipoma of Biceps Long Head: A Case Report and Current Concepts Review of Musculoskeletal Lipomas.Journal of orthopaedic case reports · 2026Article
- Prognostic Implications of MDM2 and CDK4 Co-amplification in Liposarcoma: Insights from FISH analysis for Translational Oncology.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Article
- Developing a diagnostic model to differentiate the well-differentiated lipomatous tumors based on clinicopathological characteristics.Scientific reports · 2025Article
- A case report and literature review on a large MDM2 negative retroperitoneal/psoas muscle well-differentiated liposarcoma mimicking intramuscular myxoma.Radiology case reports · 2025Article
- A Case Report and Literature Review on a Primary Dedifferentiated Liposarcoma of the Gallbladder.Cureus · 2025Article
- Leiomyosarcomas of the inferior vena cava: diagnostic features on contrast-enhanced CT, ultrasonography and MRI.Frontiers in oncology · 2025Article
- Article
- Retrospective analysis of radiological investigation of surgically excised head and neck lipomas.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024Article
- Article
- Role of clinical and multidetector computed tomography (MDCT) features in the prediction of patients with intestinal lipoma developing intussusception.Quantitative imaging in medicine and surgery · 2024Article
- Case report: a case report of excision of giant lipoma in the posterior neck.Frontiers in oncology · 2024Article
- The Predictive Role of the Histopathological Scoring System in Adipose Tumors-Lipoma, Atypical Lipomatous Tumor, and Liposarcoma.Diagnostics (Basel, Switzerland) · 2023Article
- Giant atypical lipomatous tumors of the thigh: a case series.Acta bio-medica : Atenei Parmensis · 2023Article
- Giant retroperitoneal well differentiated liposarcoma: A case report and literature review.International journal of surgery case reports · 2023Article
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study evaluated the diagnostic accuracy of clinical, radiological, and histopathological examinations for differential diagnosis between atypical lipomatous tumor (ALT)/well-differentiated liposarcoma (WDLS) and lipoma, and aimed to develop a new combined scoring system for the preoperative diagnosis of ALT/WDLS. Eighty-nine lipomas and 56 ALT/WDLS were included and their clinical characteristics, magnetic resonance imaging (MRI) findings, histological findings by hematoxylin and eosin (HE) staining were investigated. Then, univariate and multivariate logistic regression analyses were performed for the findings, and a combined scoring system consisted of predictive factors of ALT/WDLS was developed. The univariate and multivariate logistic regression analyses revealed that tumor location (lower extremity), deep site, size (> 11 cm), thick septa (> 2 mm), enhancement of septa or nodular lesions, and lipoblasts were significantly different for the diagnosis of ALT/WDLS. We developed a combined scoring system based on the six predictive factors (total 0-16 points, the cutoff was 9 points). The area under the curve was 0.945, and sensitivity was 87.6% and specificity was 91.1% by the receiver operating characteristics curve. This combined scoring system does not require special equipment and reagents such as fluorescence in situ hybridization (FISH), and anyone can use it easily in many medical institutions with high diagnostic accuracy.
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