Evidence map›Paper›PMID 34997023›Full record

ArticleScientific reports2022

Identifying gene expression profiles associated with neurogenesis and inflammation in the human subependymal zone from development through aging.

Mainá Bitar, Christin Weissleder, Hayley F North, Misaki S Clearwater, Oressia Zalucki, Glenda M Halliday, Maree J Webster, Michael Piper, Cynthia Shannon Weickert, Guy Barry

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 11 citations in OpenAlex.

  1. Registered Clinical Trials of Ayahuasca and DMT: A Scoping Review.Clinical pharmacology and therapeutics · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

Mainá BitarQIMR Berghofer Medical Research Institute, Herston, QLD, 4006, Australia.
Christin WeisslederSchizophrenia Research Laboratory, Neuroscience Research Australia, Randwick, NSW, 2031, Australia.ORCID 0000-0001-8858-9590
Hayley F NorthSchizophrenia Research Laboratory, Neuroscience Research Australia, Randwick, NSW, 2031, Australia.
Misaki S ClearwaterSchizophrenia Research Laboratory, Neuroscience Research Australia, Randwick, NSW, 2031, Australia.
Oressia ZaluckiSchool of Biomedical Sciences, The University of Queensland, Brisbane, 4072, Australia.
Glenda M HallidaySchool of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.ORCID 0000-0003-0422-8398
Maree J WebsterLaboratory of Brain Research, Stanley Medical Research Institute, Bethesda, MD, 20815, USA.
Michael PiperSchool of Biomedical Sciences, The University of Queensland, Brisbane, 4072, Australia.
Cynthia Shannon WeickertSchizophrenia Research Laboratory, Neuroscience Research Australia, Randwick, NSW, 2031, Australia.
Guy BarryQIMR Berghofer Medical Research Institute, Herston, QLD, 4006, Australia. g.barry@oncolifetx.com.
Neuroscience Research Australia · AUQIMR Berghofer Medical Research Institute · AUThe University of Queensland · AUUNSW Sydney · AUStanley Medical Research Institute · USSUNY Upstate Medical University · US

Funding

Brain Tissue Resource Centre for Alcohol ResearchR28AA012725 · NIAAA · UNIVERSITY OF SYDNEY · PI Greg Trevor Sutherland · 2012 to 2026
$7.0M
NIAAA NIH HHS R28 AA012725
6 · The paper itself

Abstract

The generation of new neurons within the mammalian forebrain continues throughout life within two main neurogenic niches, the subgranular zone (SGZ) of the hippocampal dentate gyrus, and the subependymal zone (SEZ) lining the lateral ventricles. Though the SEZ is the largest neurogenic niche in the adult human forebrain, our understanding of the mechanisms regulating neurogenesis from development through aging within this region remains limited. This is especially pertinent given that neurogenesis declines dramatically over the postnatal lifespan. Here, we performed transcriptomic profiling on the SEZ from human post-mortem tissue from eight different life-stages ranging from neonates (average age ~ 2 months old) to aged adults (average age ~ 86 years old). We identified transcripts with concomitant profiles across these decades of life and focused on three of the most distinct profiles, namely (1) genes whose expression declined sharply after birth, (2) genes whose expression increased steadily with age, and (3) genes whose expression increased sharply in old age in the SEZ. Critically, these profiles identified neuroinflammation as becoming more prevalent with advancing age within the SEZ and occurring with time courses, one gradual (starting in mid-life) and one sharper (starting in old age).

Indexed as

AdolescentAdultAgedAged, 80 and overAgingChildChild, PreschoolCohort StudiesEpendymaGene Expression ProfilingGene Expression RegulationHumansInfantInfant, NewbornInflammationMiddle Aged

Identifiers

PMID34997023
PMCPMC8742079
OpenAlexW4205737593

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.