Evidence map›Paper›PMID 34997016›Full record

ArticleScientific reports2022

Holotoxin disassembly by protein disulfide isomerase is less efficient for Escherichia coli heat-labile enterotoxin than cholera toxin.

Albert Serrano, Jessica L Guyette, Joel B Heim, Michael Taylor, Patrick Cherubin, Ute Krengel, Ken Teter, Suren A Tatulian

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. UsingBiochemistry · 2024
    Article
  7. The diverse landscape of AB5-type toxins.Engineering microbiology · 2023
    Review
  8. Article
  9. UsingbioRxiv : the preprint server for biology · 2023
    Article
  10. Review
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Albert Serrano *Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL, 32816, USA.
Jessica L Guyette *Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL, 32816, USA.
Joel B HeimDepartment of Chemistry, University of Oslo, Blindern, Oslo, Norway.
Michael TaylorBurnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL, 32816, USA.
Patrick CherubinBurnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL, 32816, USA.
Ute KrengelDepartment of Chemistry, University of Oslo, Blindern, Oslo, Norway.
Ken TeterBurnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL, 32816, USA. Kenneth.Teter@ucf.edu.
Suren A TatulianDepartment of Physics, College of Sciences, University of Central Florida, Orlando, FL, 32816, USA. statulia@ucf.edu.
University of Central Florida · USUniversity of Oslo · NONational Institutes of Health · US

Funding

The "Disaggregase" Mechanism of Holotoxin Disassembly by Protein Disulfide IsomeraseR01AI137056 · NIAID · UNIVERSITY OF CENTRAL FLORIDA · PI TETER, KENNETH R · 2018 to 2022
$2.0M
Toxin Potency is Linked to Holotoxin Disassembly by Protein Disulfide IsomeraseR03AI112854 · NIAID · UNIVERSITY OF CENTRAL FLORIDA · PI TETER, KENNETH R · 2015 to 2016
$146k
National Institutes if Health R01AI137056NIAID NIH HHS R01 AI137056NIAID NIH HHS R03 AI112854NIH HHS R03AI112854
6 · The paper itself

Abstract

Cholera toxin (CT) and Escherichia coli heat-labile enterotoxin (LT) are structurally similar AB

Indexed as

Catalytic DomainCholera ToxinEnterotoxinsEscherichia coliEscherichia coli ProteinsGlycosidesHot TemperatureMolecular Docking SimulationProtein Disulfide-IsomerasesProtein StabilityTriterpenesCholera ToxinEnterotoxinsEscherichia coli ProteinsGlycosidesProtein Disulfide-IsomerasesstichoposideTriterpenes

Identifiers

PMID34997016
PMCPMC8741891
OpenAlexW4225374945

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.