ArticleScientific reports2022
Genome-wide association study identifies tumor anatomical site-specific risk variants for colorectal cancer survival.
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Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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16citing papers in PubMed, 2 pooled it
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Colorectal Cancer Risk Loci: Prognostic Factors for Clinical Outcomes? A Systematic Review and Meta-Analysis.Cancer reports (Hoboken, N.J.) · 2025Pooled it
- Association ofGenetics research · 2022Pooled it
- Investigating the repurposing potential of immune checkpoint inhibition for cancer treatment using Mendelian randomisation.Research square · 2026Article
- A Genome-Wide Association Study of Colorectal Cancer Mortality Outcomes Among Individuals of African and Admixture Ancestry.Molecular carcinogenesis · 2026Article
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- Prognostic factors and survival outcomes in colorectal cancer: insights from a Ghanaian cohort.BMC gastroenterology · 2025Article
- Investigating the association between anthropometry and colorectal cancer survival: a two-sample Mendelian randomization analysis.International journal of epidemiology · 2025Article
- Association between methylation quantitative trait loci and colorectal cancer risk, survival and cancer recurrence.British journal of cancer · 2025Article
- Relationship between inherited genetic variation and survival from colorectal cancer stratified by tumour location.Scientific reports · 2025Article
- Article
- Integration of pathologic characteristics, genetic risk and lifestyle exposure for colorectal cancer survival assessment.Nature communications · 2024Article
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- Synergistic Antitumor Potency of a Self-Assembling Cyclodextrin Nanoplex for the Co-Delivery of 5-Fluorouracil and Interleukin-2 in the Treatment of Colorectal Cancer.Pharmaceutics · 2023Article
- Multifactor dimensionality reduction method identifies novel SNP interactions in the WNT protein interaction networks that are associated with recurrence risk in colorectal cancer.Frontiers in oncology · 2023Article
- Distant Metastasis Pattern and Prognostic Prediction Model of Colorectal Cancer Patients Based on Big Data Mining.Frontiers in oncology · 2022Article
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Authors and funding
28 authors.
Julia D LabadiePublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Sevtap SavasDiscipline of Genetics, Faculty of Medicine, Memorial University, St. John's, NL, Canada.
Tabitha A HarrisonPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Barb BanburyPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Yuhan HuangPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Daniel D BuchananCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia.
Peter T CampbellDepartment of Population Science, American Cancer Society, Atlanta, GA, USA.
Steven J GallingerLunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada.
Graham G GilesCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia.
Marc J GunterNutrition and Metabolism Section, International Agency for Research On Cancer, World Health Organization, Lyon, France.
Michael HoffmeisterDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Li HsuPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Mark A JenkinsCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia.
Yi LinPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Shuji OginoProgram in Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Amanda I PhippsPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Martha L SlatteryDepartment of Internal Medicine, University of Utah, Salt Lake City, Utah, USA.
Robert S SteinfelderPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Wei SunPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Bethany Van GuelpenDepartment of Radiation Sciences, Oncology Unit, Umeå University, Umeå, Sweden.
Xinwei HuaPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Jane C FiguieredoDepartment of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Rish K PaiDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Rami NassirDepartment of Pathology, School of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia.
Lihong QiDepartment of Public Health Sciences, University of California Davis, Davis, CA, USA.
Andrew T ChanDivision of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Ulrike PetersPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Polly A NewcombPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. pnewcomb@fredhutch.org.
Funding
Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Eric Collisson · 1985 to 2026
$296.4MStatistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ROSNER, BERNARD A · 2000 to 2019
$77.8MValidity of Diet and Activity Measures in WomenP01CA055075 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI SMITH-WARNER, STEPHANIE A · 1991 to 2009
$41.8MLong Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3MMolecular pathological epidemiology of colorectal cancerU01CA137088 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI PETERS, ULRIKE · 2009 to 2018
$21.8MCancer Epidemiology Cohort in Male Health ProfessionalsU01CA167552 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Lorelei Mucci, Walter C. Willett · 2017 to 2026
$17.0MData sharing: the Colon Cancer Family Registry CohortU01CA167551 · NCI · UNIVERSITY OF MELBOURNE · PI Daniel David BUCHANAN, Steven Gallinger · 2018 to 2026
$16.8MSEATTLE FAMILIAL COLORECTAL CANCER REGISTRYU01CA074794 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI NEWCOMB, POLLY A · 1997 to 2007
$14.1MCancer Epidemiology Cohort in Male Health ProfessionalsUM1CA167552 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI WILLETT, WALTER C. · 2012 to 2016
$11.5MTransdisciplinary Studies of Genetic Variation in Colorectal CancerU19CA148107 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GRUBER, STEPHEN B · 2010 to 2014
$11.1MGenomic Wide Association Study of Colorectal CancerU01CA122839 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CASEY, GRAHAM · 2006 to 2010
$7.3MThe Colon Cancer Family Registry: SeattleU24CA074794 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI NEWCOMB, POLLY A · 2008 to 2011
$7.0MCancer Research UK 14136Cancer Research UK C570/A16491Cancer Research UK C8221/A19170Medical Research Council G0401527Medical Research Council G1000143Medical Research Council MR/M012190/1Medical Research Council MR/N003284/1NCI NIH HHS K05 CA152715NCI NIH HHS K05 CA154337NCI NIH HHS P01 CA055075NCI NIH HHS P01 CA087969NCI NIH HHS P30 CA015704NCI NIH HHS R01 CA042182NCI NIH HHS R01 CA076366NCI NIH HHS R01 CA137178NCI NIH HHS R01 CA151993NCI NIH HHS R01 CA176272NCI NIH HHS R35 CA197735NCI NIH HHS U01 CA074794NCI NIH HHS U01 CA122839NCI NIH HHS U01 CA137088NCI NIH HHS U01 CA167551NCI NIH HHS U01 CA167552NCI NIH HHS U19 CA148107NCI NIH HHS U24 CA074794NCI NIH HHS UM1 CA167552NCI NIH HHS UM1 CA186107NHLBI NIH HHS HHSN268201100046CNHLBI NIH HHS HHSN268201200008INIA NIH HHS HHSN271201100004CWHI NIH HHS HHSN268201100001CWHI NIH HHS HHSN268201100002CWHI NIH HHS HHSN268201100003CWHI NIH HHS HHSN268201100004CWorld Health Organization 001
Abstract
Identification of new genetic markers may improve the prediction of colorectal cancer prognosis. Our objective was to examine genome-wide associations of germline genetic variants with disease-specific survival in an analysis of 16,964 cases of colorectal cancer. We analyzed genotype and colorectal cancer-specific survival data from a consortium of 15 studies. Approximately 7.5 million SNPs were examined under the log-additive model using Cox proportional hazards models, adjusting for clinical factors and principal components. Additionally, we ran secondary analyses stratifying by tumor site and disease stage. We used a genome-wide p-value threshold of 5 × 10
Indexed as
Genetic LociPolymorphism, Single NucleotideAdultAgedAged, 80 and overBiomarkers, TumorColorectal NeoplasmsDatabases, GeneticFemaleGenome-Wide Association StudyHumansMaleMiddle AgedNeoplasm StagingRisk AssessmentRisk FactorsBiomarkers, Tumor
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.