Evidence map›Paper›PMID 34996954›Full record

ArticleScientific reports2022

Blast-induced axonal degeneration in the rat cerebellum in the absence of head movement.

Robin Bishop, Seok Joon Won, Karen-Amanda Irvine, Jayinee Basu, Eric S Rome, Raymond A Swanson

Open access · goldAbstract readVideo-Audio Media
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Robin Bishop *Department of Neurology, University of California at San Francisco, San Francisco, CA, 94158, USA.
Seok Joon Won *Department of Neurology, University of California at San Francisco, San Francisco, CA, 94158, USA. Seokjoon.won@va.gov.
Karen-Amanda IrvineDepartment of Neurology, University of California at San Francisco, San Francisco, CA, 94158, USA.
Jayinee BasuDepartment of Neurology, University of California at San Francisco, San Francisco, CA, 94158, USA.
Eric S RomeDepartment of Neurology, University of California at San Francisco, San Francisco, CA, 94158, USA.
Raymond A SwansonDepartment of Neurology, University of California at San Francisco, San Francisco, CA, 94158, USA.
San Francisco VA Medical Center · USUniversity of California, San Francisco · US

Funding

Integrating pathogenic mechanisms in Parkinson's diseaseR01NS105774 · NINDS · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI SWANSON, RAYMOND A · 2018 to 2022
$1.8M
Congressionally Directed Medical Research Programs W81XWH-13-2-0091NINDS NIH HHS R01 NS105774
6 · The paper itself

Abstract

Blast exposure can injure brain by multiple mechanisms, and injury attributable to direct effects of the blast wave itself have been difficult to distinguish from that caused by rapid head displacement and other secondary processes. To resolve this issue, we used a rat model of blast exposure in which head movement was either strictly prevented or permitted in the lateral plane. Blast was found to produce axonal injury even with strict prevention of head movement. This axonal injury was restricted to the cerebellum, with the exception of injury in visual tracts secondary to ocular trauma. The cerebellar axonal injury was increased in rats in which blast-induced head movement was permitted, but the pattern of injury was unchanged. These findings support the contentions that blast per se, independent of head movement, is sufficient to induce axonal injury, and that axons in cerebellar white matter are particularly vulnerable to direct blast-induced injury.

Indexed as

Nerve DegenerationAnimalsAxonsBiomarkersBlast InjuriesBrain Injuries, TraumaticCerebellumDisease Models, AnimalHead MovementsMaleOptic NerveOptic Nerve InjuriesRatsRats, Long-EvansVisual PathwaysWhite MatterBiomarkers

Identifiers

PMID34996954
PMCPMC8741772
OpenAlexW4225696217

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.