ArticleScientific reports2022
Assessing cerebral blood flow, oxygenation and cytochrome c oxidase stability in preterm infants during the first 3 days after birth.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05941494 (Cerebral Hemodynamic and Metabolic Responses to Anesthesia and Vasopressors in Adult Surgery), which is not on this map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Cerebral Hemodynamic and Metabolic Responses to Anesthesia and Vasopressors in Adult Surgery: A 2x2 Factorial Design Randomized Controlled Trial With Light-based Neuromonitoring (CHEM-FACT Study)
Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- Neonatal cerebral hemodynamics under elevated intracranial pressure: a near-infrared spectroscopy study in piglets.Pediatric research · 2026Article
- Noninvasive diffuse optical monitoring of cerebral blood flow and oxygenation responses to intermittent hypoxia in neonatal rats.Journal of biomedical optics · 2026Article
- Noninvasive estimation of superficial layer thickness using multi-channel diffuse correlation spectroscopy.Biomedical optics express · 2025Article
- Quantification of oxidized and reduced cytochrome-c-oxidase by combining discrete-wavelength time-resolved and broadband continuous-wave near-infrared spectroscopy.Biomedical optics express · 2025Article
- The effect of hemoglobin level in early life on periventricular leukomalacia: a case control study.Scientific reports · 2025Article
- Continuous wavelet based transfer function analysis of cerebral autoregulation dynamics for neuromonitoring using near-infrared spectroscopy.Frontiers in physiology · 2025Article
- Non-invasive point-of-care optical technique for continuous in vivo assessment of microcirculatory function: Application to a preclinical model of early sepsis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024Article
- All-optics technique for monitoring absolute cerebral blood flow: validation against magnetic resonance imaging perfusion.Neurophotonics · 2024Article
- Premature newborns with intraventricular hemorrhage do not have vasospasm pattern by cranial Doppler ultrasound: A pilot study.European journal of pediatrics · 2024Article
- Review of measurements and imaging of cytochrome-c-oxidase in humans using near-infrared spectroscopy: an update.Biomedical optics express · 2024Review
- Characterization of cerebral macro- and microvascular hemodynamics during transient hypotension.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Non-invasive diffuse optical monitoring of cerebral physiology in an adult swine-model of impact traumatic brain injury.Biomedical optics express · 2023Article
- Advanced Neuromonitoring Modalities on the Horizon: Detection and Management of Acute Brain Injury in Children.Neurocritical care · 2023Review
- Fast estimation of adult cerebral blood content and oxygenation with hyperspectral time-resolved near-infrared spectroscopy.Frontiers in neuroscience · 2023Article
- Assessing the Sensitivity of Multi-Distance Hyperspectral NIRS to Changes in the Oxidation State of Cytochrome C Oxidase in the Brain.Metabolites · 2022Article
- Assessing the relationship between the cerebral metabolic rate of oxygen and the oxidation state of cytochrome-c-oxidase.Neurophotonics · 2022Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
A major concern with preterm birth is the risk of neurodevelopmental disability. Poor cerebral circulation leading to periods of hypoxia is believed to play a significant role in the etiology of preterm brain injury, with the first three days of life considered the period when the brain is most vulnerable. This study focused on monitoring cerebral perfusion and metabolism during the first 72 h after birth in preterm infants weighing less than 1500 g. Brain monitoring was performed by combining hyperspectral near-infrared spectroscopy to assess oxygen saturation and the oxidation state of cytochrome c oxidase (oxCCO), with diffuse correlation spectroscopy to monitor cerebral blood flow (CBF). In seven of eight patients, oxCCO remained independent of CBF, indicating adequate oxygen delivery despite any fluctuations in cerebral hemodynamics. In the remaining infant, a significant correlation between CBF and oxCCO was found during the monitoring periods on days 1 and 3. This infant also had the lowest baseline CBF, suggesting the impact of CBF instabilities on metabolism depends on the level of blood supply to the brain. In summary, this study demonstrated for the first time how continuous perfusion and metabolic monitoring can be achieved, opening the possibility to investigate if CBF/oxCCO monitoring could help identify preterm infants at risk of brain injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.