Evidence map›Paper›PMID 34996874›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Filip Van Hauwermeiren, Nina Van Opdenbosch, Hanne Van Gorp, Nathalia de Vasconcelos, Geert van Loo, Peter Vandenabeele, Thirumala-Devi Kanneganti, Mohamed Lamkanfi

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 21 citations in OpenAlex.

  1. Targeting the non-coding RNA-PANoptosis axis: a novel frontier in disease diagnosis and therapy.Apoptosis : an international journal on programmed cell death · 2026
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  11. Death by TNF: a road to inflammation.Nature reviews. Immunology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Filip Van HauwermeirenDepartment of Internal Medicine and Paediatrics, Ghent University, Ghent B-9000, Belgium.ORCID 0000-0001-9478-9994
Nina Van OpdenboschDepartment of Internal Medicine and Paediatrics, Ghent University, Ghent B-9000, Belgium.ORCID 0000-0001-6168-2971
Hanne Van GorpDepartment of Internal Medicine and Paediatrics, Ghent University, Ghent B-9000, Belgium.
Nathalia de VasconcelosDepartment of Internal Medicine and Paediatrics, Ghent University, Ghent B-9000, Belgium.ORCID 0000-0002-7169-6602
Geert van LooCenter for Inflammation Research, VIB, Ghent B-9000, Belgium.
Peter VandenabeeleCenter for Inflammation Research, VIB, Ghent B-9000, Belgium.
Thirumala-Devi KannegantiDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105.
Mohamed LamkanfiDepartment of Internal Medicine and Paediatrics, Ghent University, Ghent B-9000, Belgium; mohamed.lamkanfi@ugent.be.
Ghent University · BESt. Jude Children's Research Hospital · US

Funding

Role of NLR Inflammasomes in Autoinflammatory Diseases and Host DefenseR01AR056296 · NIAMS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI KANNEGANTI, THIRUMALA-DEVI · 2008 to 2022
$5.9M
Inflammatory Caspases in Innate Immunity and InflammationR37AI101935 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Thirumala-Devi Kanneganti · 2017 to 2026
$4.9M
NLR signaling in colitis and colorectal tumorigenesisR01CA163507 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI KANNEGANTI, THIRUMALA-DEVI · 2012 to 2020
$3.5M
Inflammatory Caspases in Innate Immunity and InflammationR01AI101935 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI KANNEGANTI, THIRUMALA-DEVI · 2012 to 2016
$2.2M
NCI NIH HHS R01 CA163507NIAID NIH HHS R01 AI101935NIAID NIH HHS R37 AI101935NIAMS NIH HHS R01 AR056296
6 · The paper itself

Abstract

Lethal toxin (LeTx)-mediated killing of myeloid cells is essential for

Indexed as

ApoptosisAnimalsAnthraxBacillus anthracisCaspase 8Host-Pathogen InteractionsInflammasomesInterleukin-1betaMacrophagesMiceMice, Inbred BALB CMice, Inbred C57BLNLR Family, Pyrin Domain-Containing 3 ProteinPyroptosisReceptor-Interacting Protein Serine-Threonine KinasesSignal TransductionCasp8 protein, mouseCaspase 8InflammasomesInterleukin-1betaNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseReceptor-Interacting Protein Serine-Threonine KinasesRipk1 protein, mouseanthraxapoptosisinfectionNLRP3 inflammasomeTNF

Identifiers

PMID34996874
PMCPMC8764678
OpenAlexW4205235735

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.