Evidence map›Paper›PMID 34996868›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Lipoprotein-associated phospholipase A

Varnavas D Mouchlis, Daiki Hayashi, Alexis M Vasquez, Jian Cao, J Andrew McCammon, Edward A Dennis

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 32 citations in OpenAlex.

  1. Spider venom phospholipase D toxin structure: Interfacial binding site, mechanism, activation, and head group preference.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. Review
  4. Specificity mechanism of Group VIA calcium-independent phospholipase ABiochimica et biophysica acta. Molecular and cell biology of lipids · 2025
    Article
  5. Article
  6. Unraveling the Molecular Mechanisms of ABHD5 Membrane Targeting.bioRxiv : the preprint server for biology · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Varnavas D MouchlisDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093-0601; vmouchlis@gmail.com edennis@ucsd.edu.ORCID 0000-0002-4235-1867
Daiki HayashiDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093-0601.ORCID 0000-0002-2616-448X
Alexis M VasquezDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093-0601.
Jian CaoDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093-0601.
J Andrew McCammonDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093-0601.ORCID 0000-0003-3065-1456
Edward A DennisDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093-0601; vmouchlis@gmail.com edennis@ucsd.edu.ORCID 0000-0003-3738-3140
University of California San Diego · US

Funding

THEORY OF BIOMOLECULAR DIFFUSIONR01GM031749 · NIGMS · UNIVERSITY OF HOUSTON · PI HUBER, GARY ALEXANDER, MCCAMMON, JAMES ANDREW · 1985 to 2022
$7.8M
ACTION OF LIPOLYTIC ENZYMESR01GM020501 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DENNIS, EDWARD A · 1985 to 2020
$7.3M
Action of Lipolytic EnzymesR35GM139641 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI EDWARD A DENNIS · 2021 to 2026
$2.6M
NIGMS NIH HHS R01 GM020501NIGMS NIH HHS R01 GM031749NIGMS NIH HHS R35 GM139641
6 · The paper itself

Abstract

Lipoprotein-associated phospholipase A

Indexed as

1-Alkyl-2-acetylglycerophosphocholine EsteraseAllosteric RegulationBinding SitesCatalysisCatalytic DomainFatty AcidsHumansHydrolysisLipoproteins, HDLMembranesMolecular Dynamics SimulationPhospholipidsSubstrate Specificity1-Alkyl-2-acetylglycerophosphocholine EsteraseFatty AcidsLipoproteins, HDLPhospholipidsallosterismlipidlipoproteinmembranephospholipase

Identifiers

PMID34996868
PMCPMC8764669
OpenAlexW4206361160

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.