Evidence map›Paper›PMID 34996838›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2022

Bcl-2 Is Necessary to Counteract Bim and Promote Survival of TCRαβ

Sharmila Shanmuganad, Sarah A Hummel, Vivian Varghese, David A Hildeman

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.5field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Cytotoxic T Cells: Kill, Memorize, and Mask to Maintain Immune Homeostasis.International journal of molecular sciences · 2025
    Review
  5. Notch Inhibitors and BH3 Mimetics in T-Cell Acute Lymphoblastic Leukemia.International journal of molecular sciences · 2024
    Review
  6. Review
  7. Review
  8. Development and function of natural TCRFrontiers in immunology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Sharmila ShanmuganadImmunology Graduate Program, Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH; and.
Sarah A HummelDivision of Immunobiology, Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH.ORCID 0000-0003-4446-6198
Vivian VargheseDivision of Immunobiology, Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH.
David A HildemanImmunology Graduate Program, Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH; and david.hildeman@cchmc.org.ORCID 0000-0002-0421-8483
Cincinnati Children's Hospital Medical Center · US

Funding

Regulation of Apoptosis in Activated Primary T CellsR01AI057753 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI HILDEMAN, DAVID A · 2005 to 2013
$2.8M
Manipulating DNA Damage-response Signaling for the Treatment of Type 1 DiabetesR01DK117632 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI KATZ, JONATHAN DAVID · 2019 to 2022
$1.8M
Exploiting the DNA damage response to selectively sculpt the T cellrepertoireR01AI109810 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI HILDEMAN, DAVID A, JORDAN, MICHAEL · 2014 to 2017
$1.6M
Control of Diabetes by Manipulation of Bc12 Family MembersR01DK081175 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI HILDEMAN, DAVID A, KATZ, JONATHAN DAVID · 2011 to 2014
$1.4M
Regualtion of Apoptosis in Activated Primary T CellsR56AI057753 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI HILDEMAN, DAVID A · 2008 to 2008
$375k
NIAID NIH HHS R01 AI057753NIAID NIH HHS R01 AI109810NIAID NIH HHS R56 AI057753NIDDK NIH HHS R01 DK081175NIDDK NIH HHS R01 DK117632
6 · The paper itself

Abstract

The precursors of TCRαβ

Indexed as

AnimalsBcl-2-Like Protein 11CD4 AntigensCD8 AntigensCell SurvivalCore Binding Factor Alpha 3 SubunitFemaleIntraepithelial LymphocytesMaleMiceMice, Inbred C57BLMice, KnockoutProto-Oncogene Proteins c-bcl-2Receptors, Antigen, T-Cell, alpha-betaStem CellsThymus GlandBcl2l11 protein, mouseBcl-2-Like Protein 11Bcl2 protein, mouseCD4 AntigensCD8 antigen, alpha chainCD8 AntigensCore Binding Factor Alpha 3 SubunitProto-Oncogene Proteins c-bcl-2Receptors, Antigen, T-Cell, alpha-betaRunx3 protein, mouse

Identifiers

PMID34996838
PMCPMC8982985
OpenAlexW4205290181

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.