Evidence map›Paper›PMID 34996832›Full record

ArticleThe European respiratory journal2022

The association of lung function and pulmonary vasculature volume with cardiorespiratory fitness in the community.

Jenna McNeill, Ariel Chernofsky, Matthew Nayor, Farbod N Rahaghi, Raul San Jose Estepar, George Washko, Andrew Synn, Ramachandran S Vasan, George O'Connor, Martin G Larson and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in The European respiratory journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
4.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Jenna McNeillDivision of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Ariel ChernofskyBoston University and National Heart, Lung, and Blood Institute Framingham Heart Study, Framingham, MA, USA.ORCID 0000-0002-7104-409X
Matthew NayorDivision of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Farbod N RahaghiDivision of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Raul San Jose EsteparDivision of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-3677-1996
George WashkoDivision of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Andrew SynnDivision of Pulmonary and Critical Care Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-3215-4808
Ramachandran S VasanFramingham Heart Study and Sections of Preventive Medicine and Epidemiology and Cardiovascular Medicine, Boston University School of Medicine, and Dept of Epidemiology, Boston University School of Public Health, Boston, MA, USA.
George O'ConnorFramingham Heart Study and Sections of Preventive Medicine and Epidemiology and Cardiovascular Medicine, Boston University School of Medicine, and Dept of Epidemiology, Boston University School of Public Health, Boston, MA, USA.
Martin G LarsonBoston University and National Heart, Lung, and Blood Institute Framingham Heart Study, Framingham, MA, USA.
Jennifer E HoDivision of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA, USA jho@bidmc.harvard.edu.
Gregory D LewisDivision of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-8108-8240
Boston University · USBrigham and Women's Hospital · USHarvard University · USBeth Israel Deaconess Medical Center · US

Funding

FRAMINGHAM HEART STUDY - YEAR 5 EXAM75N92019D00031 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · 2019 to 2024
$29.8M
Proteomic Profiling of Precise Exercise Pathophenotypes Across the HFpEF SpectrumR01HL131029 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Gregory Dyer Lewis, Matthew G. Nayor · 2016 to 2026
$7.7M
Eicosanoid Profiles as Determinants of HFpEFR01HL140224 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI HO, JENNIFER E · 2018 to 2021
$3.1M
The Association of Metabolic Disease and Pulmonary HypertensionR01HL134893 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI HO, JENNIFER E · 2017 to 2021
$2.9M
Characterization of Molecular and Physiologic Signatures of Impaired Multi-Organ System Reserve Capacity During Exercise in Heart Failure with Preserved Ejection FractionR01HL151841 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI LEWIS, GREGORY DYER, SHAH, RAVI · 2020 to 2023
$2.7M
Characterization of Functional Iron Deficiency and Repletion in Heart Failure with Preserved Ejection FractionR01HL159514 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI LEWIS, GREGORY DYER, MALHOTRA, RAJEEV · 2021 to 2024
$2.5M
Computed Tomographic Insights Into Pulmonary HypertensionK23HL136905 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI RAHAGHI, FARBOD NICHOLAS · 2017 to 2021
$1.1M
Metabolic Signatures of Impaired Cardiorespiratory Fitness: Correlates, Prognostic Significance and Modulation with Exercise TrainingK23HL138260 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI NAYOR, MATTHEW G. · 2017 to 2021
$998k
Mentoring in Patient-Oriented and Translational HFpEF ResearchK24HL153669 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Jennifer E Ho · 2020 to 2026
$744k
Cardiopulmonary Manifestations and Translational Potential of a Novel Radiographic Biomarker of Pulmonary Vascular MorphologyF32HL143819 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SYNN, ANDREW · 2019 to 2021
$266k
THE FRAMINGHAM HEART STUDY-N01HC25195-268025195-268025195N01HC025195 · HC · TRUSTEES OF BOSTON UNIVERSITY · PI WOLF, PHILIP A · 2002 to 2006
–
NHLBI NIH HHS 75N92019D00031NHLBI NIH HHS F32 HL143819NHLBI NIH HHS HHSN268201500001CNHLBI NIH HHS HHSN268201500001INHLBI NIH HHS K23 HL136905NHLBI NIH HHS K23 HL138260NHLBI NIH HHS K24 HL153669NHLBI NIH HHS N01 HC025195NHLBI NIH HHS R01 HL131029NHLBI NIH HHS R01 HL134893NHLBI NIH HHS R01 HL140224NHLBI NIH HHS R01 HL151841NHLBI NIH HHS R01 HL159514
6 · The paper itself

Abstract

backgroundCardiorespiratory fitness is not limited by pulmonary mechanical reasons in the majority of adults. However, the degree to which lung function contributes to exercise response patterns among ostensibly healthy individuals remains unclear.

methodsWe examined 2314 Framingham Heart Study participants who underwent cardiopulmonary exercise testing (CPET) and pulmonary function testing. We investigated the association of forced expiratory volume in 1 s (FEV

resultsWe found lower FEV

conclusionsIn a large, community-based cohort of adults, we found lower FEV

Indexed as

Cardiorespiratory FitnessAdultExercise TestExercise ToleranceHumansLungOxygenOxygen ConsumptionOxygen

Identifiers

PMID34996832
PMCPMC9259762
OpenAlexW4205877338

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.