Evidence map›Paper›PMID 34996830›Full record

SynthesisThe European respiratory journal2022

Aabida Saferali, Dandi Qiao, Wonji Kim, Karen Raraigh, Hara Levy, Alejandro A Diaz, Garry R Cutting, Michael H Cho, Craig P Hersh, NHLBI TransOmics in Precision Medicine (TOPMed)

Open access · bronzeAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The European respiratory journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Trial
  2. RNA splicing in health and disease.Molecular biomedicine · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Patient-derived cell models for personalized medicine approaches in cystic fibrosis.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2023
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Aabida SaferaliChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Dandi QiaoChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Wonji KimChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0002-1249-797X
Karen RaraighJohns Hopkins University School of Medicine, Baltimore, MD, USA.
Hara LevyDivision of Pulmonary Medicine, Dept of Pediatrics, National Jewish Health, Denver, CO, USA.
Alejandro A DiazHarvard Medical School, Boston, MA, USA.ORCID 0000-0001-5037-2919
Garry R CuttingJohns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-8250-8590
Michael H ChoChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0002-4907-1657
Craig P HershChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA craig.hersh@channing.harvard.edu.
NHLBI TransOmics in Precision Medicine (TOPMed)
Brigham and Women's Hospital · USJohns Hopkins University · USNational Jewish Health · US

Funding

Genetic Epidemiology of COPDU01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2007 to 2021
$56.9M
Genetic Epidemiology of COPDU01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2007 to 2021
$20.7M
(2 of 2) Genetic Epidemiology of COPDR01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2012 to 2016
$18.9M
SYSTEMS APPROACHES TO THE EPIDEMIOLOGY, GENETICS AND GENOMICS OF LUNG DISEASEST32HL007427 · NHLBI · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI DAWN L DEMEO, Edwin K Silverman · 1985 to 2026
$13.6M
Studies of Rare Genetic Variation in the Isolated Population of SardiniaR01HL117626 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ABECASIS, GONCALO · 2013 to 2016
$10.5M
Rare variants and NHLBI traits in deeply phenotyped cohortsR01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2014 to 2016
$8.9M
Genetic and Genomic Characterization of the Occurrence and Progression of Interstitial Lung AbnormalitiesR01HL135142 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MICHAEL H. CHO, GARY MATTHEW HUNNINGHAKE · 2017 to 2026
$7.7M
MOLECULAR GENETICS OF CYSTIC FIBROSISR01DK044003 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI Garry R Cutting · 1991 to 2026
$6.7M
Rare variants and NHLBI traits in deeply phenotyped cohortsU01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2017 to 2018
$5.6M
Genetic and Functional Dissection of a Cluster of COPD GWAS Signals on Chromosome 4qR01HL147148 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI CHO, MICHAEL H., SILVERMAN, EDWIN K · 2019 to 2022
$3.5M
SYSTEMS GENOMICS OF THE ASTHMA-COPD OVERLAP SYNDROMER01HL130512 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI HERSH, CRAIG P · 2016 to 2019
$3.5M
Identifying functional variants in COPD GWAS lociR01HL137927 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI CHO, MICHAEL H., SILVERMAN, EDWIN K · 2017 to 2020
$3.5M
NHLBI NIH HHS HHSN268201500014CNHLBI NIH HHS HHSN268201800001CNHLBI NIH HHS K01 HL129039NHLBI NIH HHS K01 HL157613NHLBI NIH HHS R01 HL089856NHLBI NIH HHS R01 HL117626NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R01 HL130512NHLBI NIH HHS R01 HL133137NHLBI NIH HHS R01 HL135142NHLBI NIH HHS R01 HL137927NHLBI NIH HHS R01 HL147148NHLBI NIH HHS R01 HL149861NHLBI NIH HHS R01 HL157879NHLBI NIH HHS T32 HL007427NHLBI NIH HHS U01 HL089856NHLBI NIH HHS U01 HL089897NHLBI NIH HHS U01 HL120393NIDDK NIH HHS R01 DK044003
6 · The paper itself

Abstract

introductionLoss-of-function variants in both copies of the cystic fibrosis transmembrane conductance regulator (

methodsWhole-genome sequencing was performed through the National Heart, Lung, and Blood Institute TOPMed (TransOmics in Precision Medicine) programme in 8597 subjects from the COPDGene (Genetic Epidemiology of COPD) study, an observational study of current and former smokers. We extracted clinically annotated

resultsWe identified 301 coding variants within the

conclusionsCigarette smokers who carry one deleterious

Indexed as

Bronchitis, ChronicCystic FibrosisPulmonary Disease, Chronic ObstructiveCystic Fibrosis Transmembrane Conductance RegulatorHumansObservational Studies as TopicSmokersCFTR protein, humanCystic Fibrosis Transmembrane Conductance Regulator

Identifiers

PMID34996830
PMCPMC9840463
OpenAlexW4205715305

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.