Evidence map›Paper›PMID 34996816›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2022

FMRP Sustains Presynaptic Function via Control of Activity-Dependent Bulk Endocytosis.

Katherine Bonnycastle, Peter C Kind, Michael A Cousin

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Dysregulation of BMP, Wnt, and Insulin Signaling in Fragile X Syndrome.Frontiers in cell and developmental biology · 2022
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Katherine BonnycastleCentre for Discovery Brain Sciences, University of Edinburgh, Edinburgh EH8 9XD, Scotland, United Kingdom.
Peter C KindCentre for Discovery Brain Sciences, University of Edinburgh, Edinburgh EH8 9XD, Scotland, United Kingdom.
Michael A CousinCentre for Discovery Brain Sciences, University of Edinburgh, Edinburgh EH8 9XD, Scotland, United Kingdom m.cousin@ed.ac.uk.ORCID 0000-0002-1762-160X
MRC Centre for Regenerative Medicine · GB

Funding

Medical Research Council MR/P006213/1
6 · The paper itself

Abstract

Synaptic vesicle (SV) recycling is essential for the maintenance of neurotransmission, with a number of neurodevelopmental disorders linked to defects in this process. Fragile X syndrome (FXS) results from a loss of fragile X mental retardation protein (FMRP) encoded by the

Indexed as

Fragile X Messenger Ribonucleoprotein 1Fragile X SyndromeAnimalsEndocytosisLarge-Conductance Calcium-Activated Potassium ChannelsMaleNeurotransmitter AgentsRatsFmr1 protein, ratFragile X Messenger Ribonucleoprotein 1Large-Conductance Calcium-Activated Potassium ChannelsNeurotransmitter AgentsendocytosisFMRPfragile X syndromepresynapsevesicle

Identifiers

PMID34996816
PMCPMC8883869
OpenAlexW4221002440

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.