ArticleVaccine2022
International links between Streptococcus pneumoniae vaccine serotype 4 sequence type (ST) 801 in Northern European shipyard outbreaks of invasive pneumococcal disease.
Article in Vaccine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Post-COVID Rebound in Invasive Pneumococcal Disease Driven by Resurgence of Serotype 4 Among American Indian Individuals in the Southwest United States.The Journal of infectious diseases · 2026Article
- Lineage Dynamics and Risk Factors Underlying Serotype 4 Invasive Pneumococcal Disease in Spain.The Journal of infectious diseases · 2026Article
- Increase in serotypes 4 and 14 in invasive pneumococcal disease in adults aged 18 to 59 years. A retrospective population-based descriptive study during the period 2007-2025 in the Community of Madrid, Spain.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Article
- Review
- Digital PCR linkage analysis resolvesMicrobiology spectrum · 2026Article
- Single-cell sequencing: accurate disease detection.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Review
- Public health effects of adult pneumococcal vaccination choice amid increased serotype 4 rates in US subpopulations.Public health · 2025Article
- ThirdEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2025Article
- The Emergent Invasive Serotype 4 ST10172 Strain Acquires vanG-Type Vancomycin-Resistance Element: A Case of a 66-Year-Old With Bacteremic Pneumococcal Pneumonia.The Journal of infectious diseases · 2025Article
- Second reported outbreak of pneumococcal pneumonia among shipyard employees in Turku, Finland, August-October 2023: a case-control study.Epidemiology and infection · 2025Article
- Streamlining marker-less allelic replacement inApplied and environmental microbiology · 2024Article
- Article
- Long-term evolution of Streptococcus mitis and Streptococcus pneumoniae leads to higher genetic diversity within rather than between human populations.PLoS genetics · 2024Article
- Vaccinating Welders against Pneumococcus: Evidence from a Systematic Review and Meta-Analysis.Vaccines · 2023Review
- Transmission factors and exposure to infections at work and invasive pneumococcal disease.American journal of industrial medicine · 2023Article
- Invasive pneumococcal disease surveillance in Canada, 2020.Canada communicable disease report = Releve des maladies transmissibles au Canada · 2022Article
Corrections and comments
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Authors and funding
22 authors.
Funding
Abstract
backgroundPneumococcal disease outbreaks of vaccine preventable serotype 4 sequence type (ST)801 in shipyards have been reported in several countries. We aimed to use genomics to establish any international links between them.
methodsSequence data from ST801-related outbreak isolates from Norway (n = 17), Finland (n = 11) and Northern Ireland (n = 2) were combined with invasive pneumococcal disease surveillance from the respective countries, and ST801-related genomes from an international collection (n = 41 of > 40,000), totalling 106 genomes. Raw data were mapped and recombination excluded before phylogenetic dating.
resultsOutbreak isolates were relatively diverse, with up to 100 SNPs (single nucleotide polymorphisms) and a common ancestor estimated around the year 2000. However, 19 Norwegian and Finnish isolates were nearly indistinguishable (0-2 SNPs) with the common ancestor dated around 2017.
conclusionThe total diversity of ST801 within the outbreaks could not be explained by recent transmission alone, suggesting that harsh environmental and associated living conditions reported in the shipyards may facilitate invasion of colonising pneumococci. However, near identical strains in the Norwegian and Finnish outbreaks does suggest that transmission between international shipyards also contributed to those outbreaks. This indicates the need for improved preventative measures in this working population including pneumococcal vaccination.
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