Evidence map›Paper›PMID 34996596›Full record

ReviewFertility and sterility2022

Evolution of the WHO "Semen" processing manual from the first (1980) to the sixth edition (2021).

Christina Wang, Michael Mbizvo, Mario P Festin, Lars Björndahl, Igor Toskin, other Editorial Board Members of the WHO Laboratory Manual for the Examination and Processing of Human Semen

Registry-linked trialOpen access · hybridAbstract readHistorical ArticleReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Fertility and sterility, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06339996 (To Investigate Supplements for Improving Male Sperm Quality and Combating Aging), which is not on this map. Cited by 48 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 1 pooled it
14.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06339996 narecruitingnot on this mapstarted 2024, after this paper: background citation

To Investigate Supplements for Improving Male Sperm Quality and Combating Aging

TypeinterventionalSponsorKaohsiung Veterans General Hospital.Ran2024 to 2025Enrolled50ConditionsUnrecognized ConditionArmsMale supplement
3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 1 synthesis or guideline pooled it, 84 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 4 countries.

Christina WangClinical and Translational Science Institute, The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, California. Electronic address: wang@lundquist.org.
Michael MbizvoReproductive Health Sciences, University of Zimbabwe and Country Director/Senior Associate, Population Council, Lusaka, Zambia.
Mario P FestinDepartment of Obstetrics and Gynecology and Department of Clinical Epidemiology, College of Medicine, University of the Philippines, Manila, Philippines.
Lars BjörndahlANOVA, Clinic for Endocrinology, Karolinska University Hospital and Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
Igor ToskinOther Editorial Board Members and Contributors of the WHO Laboratory Manual for the Examination and Processing of Human Semen, 6th edition.
other Editorial Board Members of the WHO Laboratory Manual for the Examination and Processing of Human Semen
Harbor–UCLA Medical Center · USKarolinska University Hospital · SEUniversity of the Philippines Manila · PHUniversity of Zimbabwe · ZW

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Mechanism Underlying the Transduction of Epimutations from the Soma to the Male GermlineP50HD098593 · NICHD · UNIVERSITY OF NEVADA RENO · PI SWERDLOFF, RONALD SHERWIN · 2019 to 2024
$7.2M
CCTN-CORE FUNCTION ACTIVITIES - SITE OF MALE CONTRACEPTIVE STUDIES - UCLA-LUNDQUIST75N94020D00007 · NICHD · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI SWERDLOFF, RON · 2020 to 2025
$230k
NCATS NIH HHS UL1 TR001881NICHD NIH HHS 75N94020D00007NICHD NIH HHS HHSN275200800044UNICHD NIH HHS P50 HD098593
6 · The paper itself

Abstract

As stated clearly in all editions of the WHO Laboratory Manual for the Examination and Processing of Human Semen, the goal of the manual is to meet the growing needs for the standardization of semen analysis procedures. With constant advances in andrology and reproductive medicine and the advent of sophisticated assisted reproductive technologies for the treatment of infertility, the manual has been continuously updated to meet the need for new, evidence-based, validated tests to not only measure semen and sperm variables but also to provide a functional assessment of spermatozoa. The sixth edition of the WHO manual, launched in 2021, can be freely downloaded from the WHO website, with the hope of gaining wide acceptance and utilization as the essential source of the latest, evidence-based information for laboratory procedures required for the assessment of male reproductive function and health.

Indexed as

Manuals as TopicSemen AnalysisWorld Health OrganizationDiffusion of InnovationFertilityHistory, 20th CenturyHistory, 21st CenturyHumansInfertility, MaleMaleSpermatozoaadvanced methodsbasic and extended methodsquality controlreferences rangesSemen analysis standardization

Identifiers

PMID34996596
PMCPMC8842884
OpenAlexW4205209224

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.