Evidence map›Paper›PMID 34996456›Full record

ArticleEnvironmental health : a global access science source2022

Association between exposure to radioactive iodine after the Chernobyl accident and thyroid volume in Belarus 10-15 years later.

Ekaterina Chirikova, Robert J McConnell, Patrick O'Kane, Vasilina Yauseyenka, Mark P Little, Victor Minenko, Vladimir Drozdovitch, Ilya Veyalkin, Maureen Hatch, June M Chan and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental health : a global access science source, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Ekaterina ChirikovaDepartment of Epidemiology and Biostatistics, School of Medicine, University of California, San Francisco, 550 16th Street, San Francisco, CA, 94158, USA.
Robert J McConnellThe New York Thyroid Center, Columbia University, New York, NY, USA.
Patrick O'KaneDepartment of Radiology, Thomas Jefferson University Hospital, Philadelphia, PA, USA.
Vasilina YauseyenkaRepublican Research Center for Radiation Medicine and Human Ecology, Gomel, Belarus.
Mark P LittleRadiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Victor MinenkoInstitute for Nuclear Problems, Belarusian State University, Minsk, Belarus.
Vladimir DrozdovitchRadiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Ilya VeyalkinRepublican Research Center for Radiation Medicine and Human Ecology, Gomel, Belarus.
Maureen HatchRadiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
June M ChanDepartment of Epidemiology and Biostatistics, School of Medicine, University of California, San Francisco, 550 16th Street, San Francisco, CA, 94158, USA.
Chiung-Yu HuangDepartment of Epidemiology and Biostatistics, School of Medicine, University of California, San Francisco, 550 16th Street, San Francisco, CA, 94158, USA.
Kiyohiko MabuchiRadiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Elizabeth K CahoonRadiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Alexander RozhkoRepublican Research Center for Radiation Medicine and Human Ecology, Gomel, Belarus.
Lydia B ZablotskaDepartment of Epidemiology and Biostatistics, School of Medicine, University of California, San Francisco, 550 16th Street, San Francisco, CA, 94158, USA. Lydia.Zablotska@ucsf.edu.ORCID 0000-0002-0778-1108

Funding

division of cancer epidemiology and genetics, national cancer institute NO1-CP-21178NCI NIH HHS N01 CP021178
6 · The paper itself

Abstract

backgroundWhile there is a robust literature on environmental exposure to iodine-131 (

methodsTo assess the effect of

resultsThe analysis was based on 10,703 subjects. We found a statistically significant positive association between radiation dose and thyroid volume (P < 0.001). Heterogeneity of association was observed by attained age (P < 0.001) with statistically significant association remaining only in the subgroup of ≥18 years at screening (P < 0.001). For this group, increase in dose from 0.0005 to 0.15 Gy was associated with a 1.27 ml (95% CI: 0.46, 2.07) increase in thyroid volume. The estimated effect did not change with increasing doses above 0.15 Gy.

conclusionsThis is the first study to examine the association between

Indexed as

Chernobyl Nuclear AccidentNeoplasms, Radiation-InducedThyroid NeoplasmsAdolescentCohort StudiesDose-Response Relationship, RadiationHumansIodine RadioisotopesRepublic of BelarusUkraineIodine RadioisotopesChernobyl nuclear accidentDose-response relationshipEnvironmental exposureRadiationRadioactive iodineThyroid glandThyroid pathologyThyroid volume

Identifiers

PMID34996456
PMCPMC8742457

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.