Evidence map›Paper›PMID 34996450›Full record

ArticleBMC medical ethics2022

The role of community advisory boards in community-based HIV clinical trials: a qualitative study from Tanzania.

Godwin Pancras, Bruno F Sunguya, Nathanael Sirili, Emmanuel Balandya, Eligius Lyamuya, Blandina T Mmbaga

Abstract read
In one paragraph

Article in BMC medical ethics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Godwin PancrasDepartment of Bioethics and Health Professionalism, Muhimbili University of Health and Allied Sciences, P.O. Box. 65001, Dar es Salaam, United Republic of Tanzania. katunzip@gmail.com.
Bruno F SunguyaDepartment of Community Health, Muhimbili University of Health and Allied Sciences, Dar es Salaam, United Republic of Tanzania.
Nathanael SiriliDepartment of Development Studies, Muhimbili University of Health and Allied Sciences, Dar es Salaam, United Republic of Tanzania.
Emmanuel BalandyaDepartment of Department of Physiology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, United Republic of Tanzania.
Eligius LyamuyaDepartment of Microbiology and Immunology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, United Republic of Tanzania.
Blandina T MmbagaDepartment of Pediatrics, Kilimanjaro Christian Medical University College, Kilimanjaro, United Republic of Tanzania.

Funding

To Reach the People: Transforming Health Professions Education in Tanzania (THET)R25TW011227 · FIC · MUHIMBILI UNIVERSITY/ ALLIED HLTH SCIS · PI KAAYA, EPHATA E, KWESIGABO, GIDEON PAUL · 2018 to 2022
$3.1M
FIC NIH HHS R25 TW011227
6 · The paper itself

Abstract

backgroundCommunity Advisory Boards (CAB) have become essential organs of involving communities in HIV clinical trials especially in developing countries. However, limited empirical evidence exists on the role of CABs in low and middle-income countries including Tanzania. This study aims at exploring the role of CABs in community-based HIV clinical trials conducted in Tanzania. METHODOLOGY: We adopted a phenomenological approach to purposefully select HIV clinical trial stakeholders. These included CAB members, researchers and Institutional Review Board (IRB) members in Tanzania. We conducted In-depth Interviews (IDIs) with ten participants and three Focus Group Discussions (FGDs) with eighteen participants. The data were thematically analyzed with the aid of MAXQDA software version 20.2.1.

resultsThe findings indicate that at every stage of implementation of a community-based HIV clinical trial, a functioning CAB is important for its success. This importance is based on contextualization of the informed consent process and protocol, managing rumours in the community, weighing trial risks and benefits, sensitizing the community, assisting participant recruitment, tracing and retention. However, being perceived as financial beneficiaries than community representatives emerged as a challenge to CAB members.

conclusionThe study empirically indicates the need for functioning CABs in every stage of implementation of community-based HIV clinical trials. The roles of which are interwoven in serving research goals and protecting the interests of the community and that of trial participants.

Indexed as

Advisory CommitteesHIV InfectionsClinical Trials as TopicEthics Committees, ResearchHumansQualitative ResearchTanzaniaCommunity Advisor BoardsHIV/AID clinical trialQualitative researchResearch ethics

Identifiers

PMID34996450
PMCPMC8741593

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.