ArticleBMC pediatrics2022
Blood routine risk factors for coronary artery aneurysm in infants younger than 8 months with Kawasaki disease.
Article in BMC pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.
- Neutrophil to Lymphocyte Ratio as a Biomarker for Predicting the Coronary Artery Abnormality in Kawasaki Disease: A Meta-Analysis.Disease markers · 2022Pooled it
- Coronary inflammatory imaging and clinical factors: associations with coronary artery aneurysm regression in pediatric Kawasaki disease.The international journal of cardiovascular imaging · 2026Article
- Development and validation of an interpretable machine learning model for predicting medium-to-giant coronary aneurysms in Kawasaki disease.Frontiers in immunology · 2026Article
- Platelet-related hematologic markers and genetic associations of aspirin resistance in kawasaki disease.Frontiers in molecular biosciences · 2026Article
- Decoding clinical heterogeneity and age-related coronary risk in incomplete Kawasaki disease: a multicenter cluster analysis and structural equation modeling study.Frontiers in immunology · 2026Article
- The clinical value of dynamic monitoring of complete blood count in predicting immunoglobulin resistance in Chinese children with Kawasaki disease.Scientific reports · 2025Article
- Risk Factors and Regression of Coronary Aneurysms in Infants With Kawasaki Disease.Cardiovascular therapeutics · 2025Article
- Predictive factors of medium-giant coronary artery aneurysms in Kawasaki disease.Pediatric research · 2024Article
- Relationship between serum plasminogen activator and D-dimer levels and the severity of Kawasaki disease in children as well as their predictive value for coronary artery lesion.American journal of translational research · 2024Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aims of this study were to characterize the evolution of routine blood values within the first 10 days of illness and coronary artery outcome in infants < 8 months with Kawasaki disease (KD) and to identify risk factors for coronary artery aneurysm (CAA).
methodsLaboratory data, clinical features and coronary artery outcomes from 78 infants < 8 months old and 86 patients between 8 months and 7 years old were retrospectively analyzed. Logistic regression analysis was conducted to evaluate the potential risk factors for CAA.
resultsInfants < 8 months old were more likely to present with incomplete KD (37.2% vs 4.7%, P < 0.001), erythema and induration at the BCG inoculation site (24.4% vs 3.5%, P < 0.001) and CAA (47.4% vs 15.1%, P < 0.001) even with timely diagnosis and treatment with intravenous immunoglobulin (IVIG) compared with patients ≥8 months old. Clinical feature related to diagnostic criteria for KD including bilateral conjunctival injection, oral changes, unilateral cervical lymphadenopathy and extremity changes were less common in the younger group. During the acute phase, the percentage neutrophils and neutrophil to lymphocyte ratio [NLR] peaked on median illness day 3, followed by white blood cell (WBC) and CRP on median illness day 4, hemoglobin on median illness day 7 and platelet count on median illness day 9. CAA occurred on median illness day 6 and regressed on median illness day 28. Multivariate logistic regression analysis revealed that the peak percentage neutrophils (odds ratio [OR] per 0.1: 1.597, 95% confidence interval [CI]: 1.041-2.452, P = 0.032) and the peak platelet count (OR per 10 × 10
conclusionFactors associated with CAA include a high peak percentage neutrophils, increased peak platelet count, and reduced hemoglobin within 4-6 days during the acute phase of KD. Therefore, this population should receive primary therapy with IVIG and adjunctive anti-inflammatory medications.
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