ArticleBMC anesthesiology2022
Association of hyperchloremia with all-cause mortality in patients admitted to the surgical intensive care unit: a retrospective cohort study.
Article in BMC anesthesiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
- Effect of Saline vs Gluconate/Acetate-Buffered Solution vs Lactate-Buffered Solution on Serum Chloride Among Children in the Pediatric Intensive Care Unit: The SPLYT-P Randomized Clinical Trial.JAMA pediatrics · 2023Trial
- Are Routine Labs Necessary? Postoperative Electrolyte Trends in Lipedema Patients Undergoing Liposuction: Insights from a Single-Center Retrospective Cohort.Aesthetic plastic surgery · 2026Article
- Article
- Association Between Hyperchloremia and Neurological Outcomes in Traumatic Brain Injury: A Narrative Review.Healthcare (Basel, Switzerland) · 2026Review
- Leveraging large language models for preoperative prevention of cardiopulmonary bypass-associated acute kidney injury.Renal failure · 2025Article
- Association between sodium-chloride difference at ICU admission and 30-day mortality: a retrospective cohort study of critically ill adults.BMC anesthesiology · 2025Article
- Predicting In-Hospital Mortality in Intensive Care Unit Patients Using Causal SurvivalNet With Serum Chloride and Other Causal Factors: Cross-Country Study.Journal of medical Internet research · 2025Article
- Contribution of intravenous medication diluent fluid composition on the development of dyschloremia in intensive care unit patients: A retrospective chart review.SAGE open medicine · 2025Article
- Effect of hyperchloremia on mortality of pediatric trauma patients: a retrospective cohort study.Sao Paulo medical journal = Revista paulista de medicina · 2024Article
- Pulmonary pathogenesis in a murine model of inhaled arsenical exposure.Archives of toxicology · 2023Article
- Individualizing Fluid Management in Patients with Acute Respiratory Distress Syndrome and with Reduced Lung Tissue Due to Surgery-A Narrative Review.Journal of personalized medicine · 2023Review
- Retrospective Evaluation of the Prognosis and Prevalence of Hyperchloremia in Dogs and Cats.Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSerum chloride (Cl
methodsWe enrolled 2131 patients from the Multiparameter Intelligent Monitoring in Intensive Care III database version 1.4 (MIMIC-III v1.4) from 2001 to 2012. Selected SICU patients were more than 18 years old and survived more than 72 h. A serum Cl
resultsA J-shaped correlation was observed, indicating that hyperchloremia was linked to an elevated risk of thirty-day mortality from all causes. In the multivariate analyses, it was established that hyperchloremia remained a valuable predictor of in-hospital, thirty-day and ninety-day mortality from all causes; with adjusted hazard ratios (95% CIs) for hyperchloremia of 1.35 (1.02 ~ 1.77), 1.67 (1.28 ~ 2.19), and 1.39 (1.12 ~ 1.73), respectively. In subgroup analysis, we observed hyperchloremia had a significant interaction with AKI (P for interaction: 0.017), but there were no interactions with coronary heart disease, hypertension, and diabetes mellitus (P for interaction: 0.418, 0.157, 0.103, respectively).
conclusionHyperchloremia at 72 h post-ICU admission and increasing serum Cl
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