Evidence map›Paper›PMID 34996114›Full record

Trial reportThe international journal of neuropsychopharmacology2022

Serotonin 1A Receptor Binding of [11C]CUMI-101 in Bipolar Depression Quantified Using Positron Emission Tomography: Relationship to Psychopathology and Antidepressant Response.

Martin J Lan, Francesca Zanderigo, Spiro P Pantazatos, M Elizabeth Sublette, Jeffrey Miller, R Todd Ogden, J John Mann

Registry-linked trialOpen access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The international journal of neuropsychopharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02473250 (Prediction of Clinical Response to SSRI Treatment in Bipolar Disorder Using Serotonin 1A Receptor PET Imaging), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02473250 phase4completednot on this map

Prediction of Clinical Response to SSRI Treatment in Bipolar Disorder Using Serotonin 1A Receptor PET Imaging

TypeinterventionalSponsorNew York State Psychiatric InstituteRan2015 to 2019Enrolled40ConditionsBipolar DisorderArmsFluoxetine, Citalopram
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. European psychiatry : the journal of the Association of European Psychiatrists · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Martin J LanDepartment of Psychiatry, Vagelos College of Physicians and Surgeons at Columbia University, New York, NY, USA.
Francesca ZanderigoDepartment of Psychiatry, Vagelos College of Physicians and Surgeons at Columbia University, New York, NY, USA.
Spiro P PantazatosDepartment of Psychiatry, Vagelos College of Physicians and Surgeons at Columbia University, New York, NY, USA.
M Elizabeth SubletteDepartment of Psychiatry, Vagelos College of Physicians and Surgeons at Columbia University, New York, NY, USA.
Jeffrey MillerDepartment of Psychiatry, Vagelos College of Physicians and Surgeons at Columbia University, New York, NY, USA.
R Todd OgdenDepartment of Psychiatry, Vagelos College of Physicians and Surgeons at Columbia University, New York, NY, USA.
J John MannDepartment of Psychiatry, Vagelos College of Physicians and Surgeons at Columbia University, New York, NY, USA.
Columbia University · USNew York State Psychiatric Institute

Funding

Suicidal Behavior: Aggression Subtypes, Childhood Adversity and Stress ResponseP50MH090964 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI MANN, JOSEPH JOHN · 2013 to 2022
$23.6M
Serotonin 1A Receptor PET Imaging and SSRI Outcome in Bipolar DepressionK23MH105688 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LAN, MARTIN JOSEPH · 2014 to 2018
$930k
NEUROANATOMICAL BASIS OF THE ACUTE PHASE RESPONSEF32MH010832 · NIMH · BETH ISRAEL DEACONESS MEDICAL CENTER · PI ELMQUIST, JOEL K · 1994 to 1996
–
NIMH NIH HHS F32 MH010832NIMH NIH HHS K23 MH105688NIMH NIH HHS P50 MH090964
6 · The paper itself

Abstract

backgroundThe pathophysiology of bipolar disorder (BD) remains largely unknown despite it causing significant disability and suicide risk. Serotonin signaling may play a role in the pathophysiology, but direct evidence for this is lacking. Treatment of the depressed phase of the disorder is limited. Previous studies have indicated that positron emission tomography (PET) imaging of the serotonin 1A receptor (5HT1AR) may predict antidepressant response.

methodsA total of 20 participants with BD in a current major depressive episode and 16 healthy volunteers had PET imaging with [11C]CUMI-101, employing a metabolite-corrected input function for quantification of binding potential to the 5HT1AR. Bipolar participants then received an open-labeled, 6-week clinical trial with a selective serotonin reuptake inhibitor (SSRI) in addition to their mood stabilizer. Clinical ratings were obtained at baseline and during SSRI treatment.

resultsPretreatment binding potential (BPF) of [11C]CUMI-101 was associated with a number of pretreatment clinical variables within BD participants. Within the raphe nucleus, it was inversely associated with the baseline Montgomery Åsberg Rating Scale (P = .026), the Beck Depression Inventory score (P = .0023), and the Buss Durkee Hostility Index (P = .0058), a measure of lifetime aggression. A secondary analysis found [11C]CUMI-101 BPF was higher in bipolar participants compared with healthy volunteers (P = .00275). [11C]CUMI-101 BPF did not differ between SSRI responders and non-responders (P = .907) to treatment and did not predict antidepressant response (P = .580). Voxel-wise analyses confirmed the results obtained in regions of interest analyses.

conclusionsA disturbance of serotonin system function is associated with both the diagnosis of BD and its severity of depression. Pretreatment 5HT1AR binding did not predict SSRI antidepressant outcome.The study was listed on clinicaltrials.gov with identifier NCT02473250.

Indexed as

Bipolar DisorderMajor Depressive DisorderAntidepressive AgentsCarbon RadioisotopesHumansPositron-Emission TomographyReceptor, Serotonin, 5-HT1ASelective Serotonin Reuptake InhibitorsSerotoninAntidepressive AgentsCarbon-11Carbon RadioisotopesReceptor, Serotonin, 5-HT1ASelective Serotonin Reuptake InhibitorsSerotoninAntidepressantbipolar disorderpositron emission tomographyselective serotonin reuptake inhibitorserotonin

Identifiers

PMID34996114
PMCPMC9352178
OpenAlexW4206095827

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.