ArticleProceedings of the National Academy of Sciences of the United States of America1987
Production of transforming growth factor alpha in human pancreatic cancer cells: evidence for a superagonist autocrine cycle.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
61 citing papers in PubMed, 223 citations in OpenAlex.
- Remediating Desmoplasia with EGFR-Targeted Photoactivable Multi-Inhibitor Liposomes Doubles Overall Survival in Pancreatic Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Chronic and acute arsenic exposure enhance EGFR expression via distinct molecular mechanisms.Toxicology in vitro : an international journal published in association with BIBRA · 2020Article
- NIR Photodynamic Destruction of PDAC and HNSCC Nodules Using Triple-Receptor-Targeted Photoimmuno-Nanoconjugates: Targeting Heterogeneity in Cancer.Journal of clinical medicine · 2020Article
- Impacting Pancreatic Cancer Therapy in HeterotypicNano letters · 2019Article
- Docoxahexaenoic Acid Induces Apoptosis of Pancreatic Cancer Cells by Suppressing Activation of STAT3 and NF-κB.Nutrients · 2018Article
- Molecular Drivers of Pancreatic Cancer Pathogenesis: Looking Inward to Move Forward.International journal of molecular sciences · 2017Review
- Genetic ablation of Smoothened in pancreatic fibroblasts increases acinar-ductal metaplasia.Genes & development · 2016Article
- Comparison of Kinetic Models for Dual-Tracer Receptor Concentration Imaging in Tumors.Austin journal of biomedical engineering · 2014Article
- Metabolism addiction in pancreatic cancer.Cell death & disease · 2014Review
- Advantages of a dual-tracer model over reference tissue models for binding potential measurement in tumors.Physics in medicine and biology · 2012Article
- In vivo quantification of tumor receptor binding potential with dual-reporter molecular imaging.Molecular imaging and biology · 2012Article
- High vascular delivery of EGF, but low receptor binding rate is observed in AsPC-1 tumors as compared to normal pancreas.Molecular imaging and biology · 2012Article
- Improved tumor contrast achieved by single time point dual-reporter fluorescence imaging.Journal of biomedical optics · 2012Article
- Concomitant targeting of EGF receptor, TGF-beta and SRC points to a novel therapeutic approach in pancreatic cancer.PloS one · 2012Article
- Self-induction of a/a or alpha/alpha biofilms in Candida albicans is a pheromone-based paracrine system requiring switching.Eukaryotic cell · 2011Article
- Single chain epidermal growth factor receptor antibody conjugated nanoparticles for in vivo tumor targeting and imaging.Small (Weinheim an der Bergstrasse, Germany) · 2009Article
- Intestinal hormones and growth factors: effects on the small intestine.World journal of gastroenterology · 2009Review
- Effect of disrupting seven-in-absentia homolog 2 function on lung cancer cell growth.Journal of the National Cancer Institute · 2008Article
- Article
- Systemic immune dysfunction in pancreatic cancer patients.Langenbeck's archives of surgery · 2007Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Previous work showed that cultured human pancreatic cancer cells overexpress the epidermal growth factor (EGF) receptor. In the present study, we sought to determine whether some of these cell lines produce transforming growth factor alpha (TGF-alpha). Utilizing a radiolabeled TGF-alpha cDNA in hybridization experiments, we determined that ASPC-1, T3M4, PANC-1, COLO-357, and MIA PaCa-2 cell lines expressed TGF-alpha mRNA. Serum-free medium conditioned by T3M4 and ASPC-1 cells contained significant amounts of TGF-alpha protein. Although unlabeled TGF-alpha readily competed with 125I-labeled EGF for binding, each cell line exhibited lower surface binding and internalization of 125I-labeled TGF-alpha as compared to 125I-labeled EGF. Both TGF-alpha and EGF significantly enhanced the anchorage-independent growth of PANC-1, T3M4, and ASPC-1 cells. However, TGF-alpha was 10- to 100-fold more potent than EGF. These findings suggest that the concomitant overexpression of EGF receptors and production of TGF-alpha may represent an efficient mechanism for certain cancer cells to obtain a growth advantage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.