Evidence map›Paper›PMID 34996045›Full record

ArticleThe American journal of tropical medicine and hygiene2022

COVID-19 Serology Control Panel Using the Dried-Tube Specimen Method.

William J Windsor, Vijaya Knight, Patricia A Merkel, Molly M Lamb, Heidi R Tucker, Kyle Carson, Kelly M Howard, Jennifer L Yates, Mario L Santiago, Mary K McCarthy and 10 more

Abstract read
In one paragraph

Article in The American journal of tropical medicine and hygiene, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

William J WindsorColorado School of Public Health, Anschutz Medical Campus, Aurora, Colorado.
Vijaya KnightChildren's Hospital Colorado, Anschutz Medical Campus, Aurora, Colorado.
Patricia A MerkelChildren's Hospital Colorado, Anschutz Medical Campus, Aurora, Colorado.
Molly M LambColorado School of Public Health, Anschutz Medical Campus, Aurora, Colorado.
Heidi R TuckerDivision of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, New York.
Kyle CarsonDivision of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, New York.
Kelly M HowardDivision of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, New York.
Jennifer L YatesDivision of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, New York.
Mario L SantiagoUniversity of Colorado Anschutz Medical Campus, Aurora, Colorado.
Mary K McCarthyUniversity of Colorado Anschutz Medical Campus, Aurora, Colorado.
Thomas E MorrisonUniversity of Colorado Anschutz Medical Campus, Aurora, Colorado.
Ross M KedlUniversity of Colorado Anschutz Medical Campus, Aurora, Colorado.
Ashley Frazer-AbelUniversity of Colorado Anschutz Medical Campus, Aurora, Colorado.
Kejun GuoUniversity of Colorado Anschutz Medical Campus, Aurora, Colorado.
Gillian AndersenUniversity of Colorado Anschutz Medical Campus, Aurora, Colorado.
Leah HueyChildren's Hospital Colorado, Anschutz Medical Campus, Aurora, Colorado.
Bradley S BarrettUniversity of Colorado Anschutz Medical Campus, Aurora, Colorado.
Jessica M Colón-FrancoCleveland Clinic, Cleveland, Ohio.
William T LeeDivision of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, New York.
May C ChuColorado School of Public Health, Anschutz Medical Campus, Aurora, Colorado.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The dried-tube specimen (DTS) procedure was used to develop the COVID-19 serology control panel (CSCP). The DTS offers the benefit of shipping materials without a cold chain, allowing for greater access without deterioration of material integrity. Samples in the panel were sourced from COVID-19 convalescent persons from March to May 2020. The immunoglobulin subtypes (total Ig, IgM, and IgG) and their respective reactivity to severe acute respiratory syndrome coronavirus 2 nucleocapsid, spike, and receptor-binding domain antigens of the samples were delineated and compared with the WHO International Standard to elucidate the exact binding antibody units of each CSCP sample and ensure the CSCP provides adequate reactivity for different types of serological test platforms. We distribute the CSCP as a kit with five coded tubes to laboratories around the world to be used to compare test kits for external quality assurance, for harmonizing laboratory testing, and for use as training materials for laboratory workers.

Indexed as

Antibodies, ViralCoronavirus Nucleocapsid ProteinsCOVID-19COVID-19 Serological TestingHumansImmunoglobulin GImmunoglobulin MSARS-CoV-2Specimen HandlingSpike Glycoprotein, CoronavirusWorld Health OrganizationAntibodies, ViralCoronavirus Nucleocapsid ProteinsImmunoglobulin GImmunoglobulin MN protein, SARS-CoVSpike Glycoprotein, Coronavirusspike glycoprotein, SARS-CoV

Identifiers

PMID34996045
PMCPMC8832945

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.