SynthesisNeuroImage. Clinical2022
MRI markers of functional connectivity and tissue microstructure in stroke-related motor rehabilitation: A systematic review.
Synthesis in NeuroImage. Clinical, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Immersive virtual reality-based rehabilitation for subacute stroke: a randomized controlled trial.Journal of neurology · 2024Trial
- Can specific virtual reality combined with conventional rehabilitation improve poststroke hand motor function? A randomized clinical trial.Journal of neuroengineering and rehabilitation · 2023Trial
- Progress in Intra-Arterial Stem Cell Therapy for Ischemic Stroke: A Review.Stroke (Hoboken, N.J.) · 2026Review
- Longitudinal alterations in static and dynamic functional connectivity in basal ganglia ischaemic stroke: implications for neurological recovery.Neuroradiology · 2026Article
- Associations Between Early Functional Brain Network Topology and 6-Month Upper Limb Motor Outcomes in Stroke Patients.Translational stroke research · 2026Article
- Visuomotor training induces network reorganisation of frontal eye field and cuneus connectivity: A task-based fMRI study.Neuroimage. Reports · 2026Article
- Clinical trials and advanced MRI techniques with stem cell therapy for ischemic stroke: present and future perspectives.Journal of translational medicine · 2025Review
- Post-stroke brain functional reorganization is associated with glymphatic dysfunction during stroke recovery.Brain informatics · 2025Article
- Changes in the Relationship Between Gray Matter, Functional Parameters, and Quality of Life in Patients with a Post-Stroke Spastic Upper Limb After Single-Event Multilevel Surgery: Six-Month Results from a Randomized Trial.Diagnostics (Basel, Switzerland) · 2025Article
- Neural repair mechanisms after ischemic stroke.Inflammation and regeneration · 2025Review
- Immediate modulation effects of Tongue Tri-needle on brain functional networks in infratentorial stroke patients with dysphagia: a randomized controlled trial.Frontiers in neurology · 2025Article
- Efficacy of a Rehabilitation Treatment Using Action Observation Therapy Enhanced by Muscle Synergy-Derived Electrical Stimulation (OTHELLO) in Post-Stroke Patients: A RCT Study Protocol.Journal of central nervous system disease · 2025Article
- Deciphering aquaporin-4's influence on perivascular diffusion indices using DTI in rat stroke studies.Frontiers in neuroscience · 2025Article
- Distinct and additive effects of visual and vibratory feedback for motor rehabilitation: an EEG study in healthy subjects.Journal of neuroengineering and rehabilitation · 2024Article
- Neuroimaging to Facilitate Clinical Trials in Huntington's Disease: Current Opinion from the EHDN Imaging Working Group.Journal of Huntington's disease · 2024Review
- DTI-ALPS: An MR biomarker for motor dysfunction in patients with subacute ischemic stroke.Frontiers in neuroscience · 2023Article
- Motor imagery brain-computer interface rehabilitation system enhances upper limb performance and improves brain activity in stroke patients: A clinical study.Frontiers in human neuroscience · 2023Article
- Emerging Limb Rehabilitation Therapy After Post-stroke Motor Recovery.Frontiers in aging neuroscience · 2022Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStroke-related disability is a major problem at individual and socio-economic levels. Neuromotor rehabilitation has a key role for its dual action on affected body segment and brain reorganization. Despite its known efficacy in clinical practice, the extent and type of effect at a brain level, mediated by neuroplasticity, are still under question.
objectiveTo analyze studies applying MRI markers of functional and structural connectivity in patients affected with stroke undergoing motor rehabilitation, and to evaluate the effect of rehabilitation on brain reorganization.
methodsPreferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) criteria were applied to select studies applying quantitative non-conventional MRI techniques on patients undergoing motor rehabilitation, both physical and virtual (virtual reality, mental imagery). Literature search was conducted using MEDLINE (via PubMed), Cochrane Central Register of Controlled Trials (CENTRAL), and EMBASE from inception to 30th June 2020.
resultsForty-one out of 6983 papers were included in the current review. Selected studies are heterogeneous in terms of patient characteristics as well as type, duration and frequency of rehabilitative approach. Neuromotor rehabilitation promotes neuroplasticity, favoring functional recovery of the ipsilesional hemisphere and activation of anatomically and functionally related brain areas in both hemispheres, to compensate for damaged tissue.
conclusionsThe evidence derived from the analyzed studies supports the positive impact of rehabilitation on brain reorganization, despite the high data heterogeneity. Advanced MRI techniques provide reliable markers of structural and functional connectivity that may potentially aid in helping to implement the most appropriate rehabilitation intervention.
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