Evidence map›Paper›PMID 34995836›Full record

ArticleBiosensors & bioelectronics2022

A fully implantable wireless bidirectional neuromodulation system for mice.

Jason P Wright, Ibrahim T Mughrabi, Jason Wong, Jose Mathew, Naveen Jayaprakash, Christine Crosfield, Eric H Chang, Sangeeta S Chavan, Kevin J Tracey, Valentin A Pavlov and 4 more

Open access · greenAbstract read
In one paragraph

Article in Biosensors & bioelectronics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 52 citations in OpenAlex.

  1. Article
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  7. Article
  8. Dysregulated neural coding in the vagus nerve during long sepsis.Brain, behavior, & immunity - health · 2025
    Article
  9. Article
  10. Article
  11. Review
  12. Article
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  14. Optimization of activity-driven event detection for long-term ambulatory urodynamics.Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine · 2024
    Article
  15. Review
  16. Article
  17. Living-Neuron-Based Autogenerator.Sensors (Basel, Switzerland) · 2023
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Jason P WrightInstitute of Bioelectronic Medicine, The Feinstein Institutes for Medical Research, Northwell Health, 350 Community Dr, Manhasset, NY, United States.
Ibrahim T MughrabiInstitute of Bioelectronic Medicine, The Feinstein Institutes for Medical Research, Northwell Health, 350 Community Dr, Manhasset, NY, United States.
Jason WongInstitute of Bioelectronic Medicine, The Feinstein Institutes for Medical Research, Northwell Health, 350 Community Dr, Manhasset, NY, United States.
Jose MathewInstitute of Bioelectronic Medicine, The Feinstein Institutes for Medical Research, Northwell Health, 350 Community Dr, Manhasset, NY, United States.
Naveen JayaprakashInstitute of Bioelectronic Medicine, The Feinstein Institutes for Medical Research, Northwell Health, 350 Community Dr, Manhasset, NY, United States.
Christine CrosfieldInstitute of Bioelectronic Medicine, The Feinstein Institutes for Medical Research, Northwell Health, 350 Community Dr, Manhasset, NY, United States.
Eric H ChangInstitute of Bioelectronic Medicine, The Feinstein Institutes for Medical Research, Northwell Health, 350 Community Dr, Manhasset, NY, United States.
Sangeeta S ChavanInstitute of Bioelectronic Medicine, The Feinstein Institutes for Medical Research, Northwell Health, 350 Community Dr, Manhasset, NY, United States.
Kevin J TraceyInstitute of Bioelectronic Medicine, The Feinstein Institutes for Medical Research, Northwell Health, 350 Community Dr, Manhasset, NY, United States.
Valentin A PavlovInstitute of Bioelectronic Medicine, The Feinstein Institutes for Medical Research, Northwell Health, 350 Community Dr, Manhasset, NY, United States.
Yousef Al-AbedInstitute of Bioelectronic Medicine, The Feinstein Institutes for Medical Research, Northwell Health, 350 Community Dr, Manhasset, NY, United States.
Theodoros P ZanosInstitute of Bioelectronic Medicine, The Feinstein Institutes for Medical Research, Northwell Health, 350 Community Dr, Manhasset, NY, United States.
Stavros ZanosInstitute of Bioelectronic Medicine, The Feinstein Institutes for Medical Research, Northwell Health, 350 Community Dr, Manhasset, NY, United States.
Timir Datta-ChaudhuriInstitute of Bioelectronic Medicine, The Feinstein Institutes for Medical Research, Northwell Health, 350 Community Dr, Manhasset, NY, United States. Electronic address: tdatta@northwell.edu.
Northwell Health · US

Funding

Molecular Basis of Bioelectronic MedicineR35GM118182 · NIGMS · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI TRACEY, KEVIN J · 2016 to 2025
$7.3M
The ion channel TRPA1 is required for suppression of inflammation in sepsisR01GM132672 · NIGMS · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI CHAVAN, SANGEETA S. · 2019 to 2025
$1.7M
Encoding of inflammatory mediators by vagal sensory neuronsR01GM143362 · NIGMS · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI CHANG, ERIC HAU-YUN · 2021 to 2024
$1.6M
NIGMS NIH HHS R01 GM132672NIGMS NIH HHS R01 GM143362NIGMS NIH HHS R35 GM118182
6 · The paper itself

Abstract

Novel research in the field of bioelectronic medicine requires neuromodulation systems that pair high-performance neurostimulation and bio-signal acquisition hardware with advanced signal processing and control algorithms. Although mice are the most commonly used animal in medical research, the size, weight, and power requirements of such bioelectronic systems either preclude use in mice or impose significant constraints on experimental design. Here, a fully-implantable recording and stimulation neuromodulation system suitable for use in mice is presented, measuring 2.2 cm

Indexed as

Biosensing TechniquesWireless TechnologyAnimalsElectric Power SuppliesMiceProstheses and ImplantsSignal Processing, Computer-AssistedBiocompatible packagingImplantable devicesNeuromodulationPeripheral nerve stimulationWireless systems

Identifiers

PMID34995836
PMCPMC9258776
OpenAlexW4220931480

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.