Evidence map›Paper›PMID 34995525›Full record

ArticleAmerican journal of ophthalmology2022

Corneal Edema and Keratoplasty: Risk Factors in Eyes With Previous Glaucoma Drainage Devices.

Bradley Beatson, Jiangxia Wang, Michael V Boland, Pradeep Ramulu, Oliver Schein, Michael J Fliotsos, Michael E Sulewski, Divya Srikumaran

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of ophthalmology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

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  13. Glaucoma surgery success and corneal graft survival in patients with prior corneal transplantation: A retrospective cohort study.Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological Society
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Bradley BeatsonFrom the Wilmer Eye Institute, Johns Hopkins University School of Medicine (B.B., M.V.B., P.R., O.S., M.J.F., M.E.S., D.S.), Baltimore, Maryland.
Jiangxia WangDepartment of Biostatistics, Johns Hopkins University Bloomberg School of Public Health (J.W.), Baltimore, Maryland.
Michael V BolandFrom the Wilmer Eye Institute, Johns Hopkins University School of Medicine (B.B., M.V.B., P.R., O.S., M.J.F., M.E.S., D.S.), Baltimore, Maryland; Massachusetts Eye and Ear, Harvard Medical School (M.V.B.), Boston, Massachusetts.
Pradeep RamuluFrom the Wilmer Eye Institute, Johns Hopkins University School of Medicine (B.B., M.V.B., P.R., O.S., M.J.F., M.E.S., D.S.), Baltimore, Maryland.
Oliver ScheinFrom the Wilmer Eye Institute, Johns Hopkins University School of Medicine (B.B., M.V.B., P.R., O.S., M.J.F., M.E.S., D.S.), Baltimore, Maryland.
Michael J FliotsosFrom the Wilmer Eye Institute, Johns Hopkins University School of Medicine (B.B., M.V.B., P.R., O.S., M.J.F., M.E.S., D.S.), Baltimore, Maryland.
Michael E SulewskiFrom the Wilmer Eye Institute, Johns Hopkins University School of Medicine (B.B., M.V.B., P.R., O.S., M.J.F., M.E.S., D.S.), Baltimore, Maryland.
Divya SrikumaranFrom the Wilmer Eye Institute, Johns Hopkins University School of Medicine (B.B., M.V.B., P.R., O.S., M.J.F., M.E.S., D.S.), Baltimore, Maryland. Electronic address: dsrikum1@jhmi.edu.
Johns Hopkins University · USMassachusetts Eye and Ear Infirmary · US

Funding

Wilmer Core Grant for Vision ResearchP30EY001765 · NEI · JOHNS HOPKINS UNIVERSITY · PI Jiang Qian · 1985 to 2026
$22.1M
NEI NIH HHS P30 EY001765
6 · The paper itself

Abstract

purposeTo assess risk factors contributing to corneal decompensation following glaucoma drainage device (GDD) implantation.

designRetrospective case control study.

methodsRecords of 1610 eyes that underwent GDD implantation between June 1, 2009, and April 1, 2020, at the Johns Hopkins Wilmer Eye Institute were reviewed. Seventy-nine eyes (5%) developed corneal decompensation, of which 46 underwent keratoplasty. These 79 cases were matched with 220 controls. Cox proportional hazard models with robust standard error estimates to account for clustering at the matched-pair level were used to assess risk factors for corneal decompensation. Kaplan-Meier survival analysis analyzed time to corneal decompensation.

resultsThe mean (SD) age of cases and controls was 68 (12.3) and 60.5 (15.9) years, respectively. The mean time from GDD implantation to corneal decompensation was 32 months, and the cumulative probability of developing decompensation at 3, 6, and 9 years was 4.7%, 9.2%, and 14.8%, respectively. Final visual outcomes in cases were worse, with a final mean ± SD visual acuity (logMAR) of 1.96±1.25 relative to a mean±SD visual acuity of 1.11±1.36 in controls (P < .001). In the multivariable model, significant risk factors for corneal decompensation were increased age (adjusted hazard ratio [AHR] 1.39, 95% CI 1.18, 1.63; P ≤ .001), history of Fuchs dystrophy or iridocorneal endothelial syndrome (AHR 9.18, 95% CI 5.35, 15.74; P ≤ .001), and postoperative complications such as hypotony (AHR 3.25, 95% CI 1.85, 5.72; P ≤ .001) and tube-cornea touch (AHR 6.37, 95% CI 3.77, 10.75; P ≤ .001).

conclusionsThe risk of postoperative corneal decompensation is persistent over time. Patients receiving GDDs, particularly those with advanced age, preexisting corneal pathology, and postoperative complications, should be counseled regarding their increased risk for corneal decompensation.

Indexed as

Corneal DiseasesCorneal EdemaDescemet Stripping Endothelial KeratoplastyGlaucomaGlaucoma Drainage ImplantsCase-Control StudiesFollow-Up StudiesHumansIntraocular PressurePostoperative ComplicationsRetrospective StudiesRisk FactorsTreatment Outcomecorneal decompensationcorneal edemaglaucoma drainage devicekeratoplastyrisk factorstube shunt

Identifiers

PMID34995525
PMCPMC9149105
OpenAlexW4205096158

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.