Evidence map›Paper›PMID 34995387›Full record

ArticleExperimental dermatology2022

Disturbed expression of vitamin D and retinoic acid-related orphan receptors α and γ and of megalin in inflammatory skin diseases.

Anna A Brożyna, Michał A Żmijewski, Kinga Linowiecka, Tae-Kang Kim, Radomir M Slominski, Andrzej T Slominski

Open access · greenAbstract read
In one paragraph

Article in Experimental dermatology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Retinoic acid in health and disease.Signal transduction and targeted therapy · 2026
    Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Vitamin D Signaling in Psoriasis: Pathogenesis and Therapy.International journal of molecular sciences · 2022
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Anna A BrożynaDepartment of Human Biology, Institute of Biology, Faculty of Biological and Veterinary Sciences, Nicolaus Copernicus University, Toruń, Poland.ORCID 0000-0002-3195-9965
Michał A ŻmijewskiFaculty of Medicine, Department of Histology, Medical University of Gdańsk, Gdańsk, Poland.ORCID 0000-0003-2206-3531
Kinga LinowieckaDepartment of Human Biology, Institute of Biology, Faculty of Biological and Veterinary Sciences, Nicolaus Copernicus University, Toruń, Poland.ORCID 0000-0002-7029-2657
Tae-Kang KimDepartments of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID 0000-0003-1394-4134
Radomir M SlominskiDepartments of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID 0000-0002-2929-1118
Andrzej T SlominskiDepartments of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID 0000-0001-8963-3995
University of Alabama at Birmingham · USNicolaus Copernicus University · PLGdańsk Medical University · PL

Funding

XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Robert S Welner · 1985 to 2026
$165.9M
Mechanism of action and function of novel secosteroid 20(OH)D3 in the skinR01AR073004 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ANDRZEJ T SLOMINSKI · 2018 to 2026
$2.9M
Significance of metabolic activation of lumisterol in the skinR01AR071189 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SLOMINSKI, ANDRZEJ T · 2017 to 2021
$1.6M
Canonical and non-canonical vitamin D activation pathways in systemic lupusR21AI149267 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI RAMAN, CHANDER, SLOMINSKI, ANDRZEJ T · 2020 to 2021
$408k
CYP11A1-derived secosteroids as therapeutic agents in UVB induced skin cancerI01BX004293 · VA · BIRMINGHAM VA MEDICAL CENTER · PI SLOMINSKI, ANDRZEJ T · 2019 to 2025
–
BLRD VA I01 BX004293NCI NIH HHS P30 CA013148NIAID NIH HHS R21 AI149267NIAMS NIH HHS R01 AR071189NIAMS NIH HHS R01 AR073004
6 · The paper itself

Abstract

The pathogenesis of inflammatory skin diseases is associated with the abnormal activity of keratinocytes and immune cells infiltrate. Vitamin D

Indexed as

DermatitisVitamin DHumansLow Density Lipoprotein Receptor-Related Protein-2Nuclear Receptor Subfamily 1, Group F, Member 1Nuclear Receptor Subfamily 1, Group F, Member 3Receptors, CalcitriolRetinoic Acid Receptor alphaTretinoinVitaminsLow Density Lipoprotein Receptor-Related Protein-2LRP2 protein, humanNuclear Receptor Subfamily 1, Group F, Member 1Nuclear Receptor Subfamily 1, Group F, Member 3Receptors, CalcitriolRetinoic Acid Receptor alphaRORA protein, humanTretinoinVDR protein, humanVitamin DVitaminsallergic contact dermatitislichen simplex chronicusmegalinnuclear receptorspsoriasissarcoidosisvitamin D

Identifiers

PMID34995387
PMCPMC9064941
OpenAlexW4205443637

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.