Evidence map›Paper›PMID 34995346›Full record

ArticleDiabetes care2022

Trends in Glycemic Control Among Youth and Young Adults With Diabetes: The SEARCH for Diabetes in Youth Study.

Faisal S Malik, Katherine A Sauder, Scott Isom, Beth A Reboussin, Dana Dabelea, Jean M Lawrence, Alissa Roberts, Elizabeth J Mayer-Davis, Santica Marcovina, Lawrence Dolan and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in Diabetes care, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 1 pooled it
8.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 1 country.

Faisal S MalikDepartment of Pediatrics, University of Washington, Seattle, WA.ORCID 0000-0002-2543-4214
Katherine A SauderDepartment of Epidemiology, Colorado School of Public Health, Aurora, CO.ORCID 0000-0002-8473-8015
Scott IsomDepartment of Biostatistical Sciences, Wake Forest University School of Medicine, Winston-Salem, NC.
Beth A ReboussinDepartment of Biostatistical Sciences, Wake Forest University School of Medicine, Winston-Salem, NC.
Dana DabeleaDepartment of Epidemiology, Colorado School of Public Health, Aurora, CO.ORCID 0000-0001-9514-8929
Jean M LawrenceDepartment of Research & Evaluation, Kaiser Permanente Southern California, Pasadena, CA.ORCID 0000-0002-2480-8480
Alissa RobertsDepartment of Pediatrics, University of Washington, Seattle, WA.ORCID 0000-0002-0221-6273
Elizabeth J Mayer-DavisDepartments of Nutrition and Medicine, University of North Carolina, Chapel Hill, NC.ORCID 0000-0003-3858-0517
Santica MarcovinaMedpace Reference Laboratories, Cincinnati, OH.
Lawrence DolanDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH.
Daria IgudesmanDepartments of Nutrition and Medicine, University of North Carolina, Chapel Hill, NC.ORCID 0000-0001-5209-4625
Catherine PihokerDepartment of Pediatrics, University of Washington, Seattle, WA.ORCID 0000-0001-9074-7770
SEARCH for Diabetes in Youth Study
University of Washington · USColorado School of Public Health · USUniversity of North Carolina at Chapel Hill · USWake Forest University · USKaiser Permanente · USMedpace (United States) · USUniversity of Cincinnati Medical Center · US

Funding

Limited Competition for the Continuation of the SEARCH for Diabetes in Youth Cohort Study (UC4)SEARCH for Diabetes in Youth Cohort StudyUC4DK108173 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI DAGOSTINO, RALPH B. · 2015 to 2016
$14.8M
Research BaseP30DK092926 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MARY ELLEN MICHELE HEISLER, ADESUWA B OLOMU · 2011 to 2026
$10.0M
SEARCH for Diabetes in Youth Coordinating CenterU01DP000250 · DP · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI BELL, RONNY A · 2005 to 2009
$4.8M
Population-based Diabetes Youth RegistryU18DP006131 · DP · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI WAGENKNECHT, LYNNE E · 2015 to 2019
$3.8M
SEARCH For Diabetes in Youth, Phase 3: Cohort Study-Carolina CenterU18DP002708 · DP · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MAYER-DAVIS, ELIZABETH J · 2010 to 2014
$3.6M
SEARCH for Diabetes in Youth 2: Colorado CenterU01DP000247 · DP · UNIVERSITY OF COLORADO DENVER · PI DABELEA, DANA · 2005 to 2009
$3.6M
SEARCH for Diabetes in Youth 2: South Carolina CenterU01DP000254 · DP · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MAYER-DAVIS, ELIZABETH J · 2005 to 2009
$3.5M
SEARCH for Diabetes in Youth 3: Washington Site, Part BU18DP002710 · DP · SEATTLE CHILDREN'S HOSPITAL · PI PIHOKER, CATHERINE · 2010 to 2014
$3.2M
SEARCH 3 Cohort Study to Assess Incidence of Acute and Chronic Diabetes-related CU18DP002709 · DP · CINCINNATI CHILDRENS HOSP MED CTR · PI DOLAN, LAWRENCE M · 2010 to 2014
$3.2M
SEARCH for Diabetes in Youth, Phase 3: Cohort Study - California CenterU18DP002714 · DP · KAISER FOUNDATION RESEARCH INSTITUTE · PI LAWRENCE, JEAN MARIE · 2010 to 2014
$3.1M
SEARCH for Diabetes in Youth 2: California CenterU01DP000246 · DP · KAISER FOUNDATION RESEARCH INSTITUTE · PI LAWRENCE, JEAN MARIE · 2005 to 2009
$2.8M
SEARCH for Diabetes in Youth 2: Washington SiteU01DP000244 · DP · SEATTLE CHILDREN'S HOSPITAL · PI PIHOKER, CATHERINE · 2005 to 2009
$2.7M
ACL HHS U18DP006131ACL HHS U18DP006133ACL HHS U18DP006134ACL HHS U18DP006136ACL HHS U18DP006138ACL HHS U18DP006139EPA EP-C-15-002HSRD VA HIR 10-001NCCDPHP CDC HHS U01 DP000244NCCDPHP CDC HHS U01 DP000246NCCDPHP CDC HHS U01 DP000247NCCDPHP CDC HHS U01 DP000248NCCDPHP CDC HHS U01 DP000250NCCDPHP CDC HHS U01 DP000254NCCDPHP CDC HHS U18 DP002708NCCDPHP CDC HHS U18 DP002709NCCDPHP CDC HHS U18 DP002710NCCDPHP CDC HHS U18 DP002714NCCDPHP CDC HHS U18 DP006131NCCDPHP CDC HHS U18 DP006133NCCDPHP CDC HHS U18 DP006134NCCDPHP CDC HHS U18 DP006136NCCDPHP CDC HHS U18 DP006138NCCDPHP CDC HHS U18 DP006139NHLBI NIH HHS K23 HL148394NHLBI NIH HHS L40 HL148910NIDDK NIH HHS K23 DK119465NIDDK NIH HHS P30 DK092926NIDDK NIH HHS R01 DK127208NIDDK NIH HHS UC4 DK108173
6 · The paper itself

Abstract

objectiveTo describe temporal trends and correlates of glycemic control in youth and young adults (YYA) with youth-onset diabetes. RESEARCH DESIGN AND

methodsThe study included 6,369 participants with type 1 or type 2 diabetes from the SEARCH for Diabetes in Youth study. Participant visit data were categorized into time periods of 2002-2007, 2008-2013, and 2014-2019, diabetes durations of 1-4, 5-9, and ≥10 years, and age groups of 1-9, 10-14, 15-19, 20-24, and ≥25 years. Participants contributed one randomly selected data point to each duration and age group per time period. Multivariable regression models were used to test differences in hemoglobin A1c (HbA1c) over time by diabetes type. Models were adjusted for site, age, sex, race/ethnicity, household income, health insurance status, insulin regimen, and diabetes duration, overall and stratified for each diabetes duration and age group.

resultsAdjusted mean HbA1c for the 2014-2019 cohort of YYA with type 1 diabetes was 8.8 ± 0.04%. YYA with type 1 diabetes in the 10-14-, 15-19-, and 20-24-year-old age groups from the 2014-2019 cohort had worse glycemic control than the 2002-2007 cohort. Race/ethnicity, household income, and treatment regimen predicted differences in glycemic control in participants with type 1 diabetes from the 2014-2019 cohort. Adjusted mean HbA1c was 8.6 ± 0.12% for 2014-2019 YYA with type 2 diabetes. Participants aged ≥25 years with type 2 diabetes had worse glycemic control relative to the 2008-2013 cohort. Only treatment regimen was associated with differences in glycemic control in participants with type 2 diabetes.

conclusionsDespite advances in diabetes technologies, medications, and dissemination of more aggressive glycemic targets, many current YYA are less likely to achieve desired glycemic control relative to earlier cohorts.

Indexed as

Diabetes Mellitus, Type 1Diabetes Mellitus, Type 2AdolescentAdultBlood GlucoseChildChild, PreschoolFemaleGlycated HemoglobinGlycemic ControlHumansInfantMaleYoung AdultBlood GlucoseGlycated Hemoglobin

Identifiers

PMID34995346
PMCPMC8914430
OpenAlexW4205408536

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.