Evidence map›Paper›PMID 34995063›Full record

ArticleInorganic chemistry2022

Inhibition of Microtubule Dynamics in Cancer Cells by Indole-Modified Latonduine Derivatives and Their Metal Complexes.

Christopher Wittmann, Anastasiia S Sivchenko, Felix Bacher, Kelvin K H Tong, Navjot Guru, Thomas Wilson, Junior Gonzales, Hartmut Rauch, Susanne Kossatz, Thomas Reiner and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Inorganic chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Indolo[2,3-Dalton transactions (Cambridge, England : 2003) · 2023
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 4 countries.

Christopher WittmannUniversity of Vienna, Institute of Inorganic Chemistry, Währinger Strasse 42, A-1090 Vienna, Austria.
Anastasiia S SivchenkoDrug Discovery Lab, Department of Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Hong Kong SAR 999077, PR China.
Felix BacherUniversity of Vienna, Institute of Inorganic Chemistry, Währinger Strasse 42, A-1090 Vienna, Austria.
Kelvin K H TongDrug Discovery Lab, Department of Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Hong Kong SAR 999077, PR China.
Navjot GuruDepartment of Radiology, Memorial Sloan Kettering Cancer Center, 417 East 68th Street, New York, New York 10065, United States.
Thomas WilsonDepartment of Radiology, Memorial Sloan Kettering Cancer Center, 417 East 68th Street, New York, New York 10065, United States.
Junior GonzalesDepartment of Radiology, Memorial Sloan Kettering Cancer Center, 417 East 68th Street, New York, New York 10065, United States.
Hartmut RauchDepartment of Nuclear Medicine, University Hospital Klinikum Rechts der Isar, Technical University Munich, 81675 Munich, Germany.
Susanne KossatzDepartment of Nuclear Medicine, University Hospital Klinikum Rechts der Isar, Technical University Munich, 81675 Munich, Germany.
Thomas ReinerDepartment of Radiology, Memorial Sloan Kettering Cancer Center, 417 East 68th Street, New York, New York 10065, United States.
Maria V BabakDrug Discovery Lab, Department of Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Hong Kong SAR 999077, PR China.ORCID https://orcid.org/0000-0002-2009-7837
Vladimir B ArionUniversity of Vienna, Institute of Inorganic Chemistry, Währinger Strasse 42, A-1090 Vienna, Austria.ORCID https://orcid.org/0000-0002-1895-6460
Memorial Sloan Kettering Cancer Center · USCity University of Hong Kong · HKUniversity of Vienna · ATTUM Klinikum · DE

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Indolo[2,3-

Indexed as

AnimalsAntineoplastic AgentsCell SurvivalCoordination ComplexesCrystallography, X-RayDrug Screening Assays, AntitumorHeterocyclic Compounds, 3-RingHumansIndolesMammary Neoplasms, ExperimentalMiceMice, NudeMicroscopy, FluorescenceMicrotubulesModels, MolecularMolecular StructureAntineoplastic AgentsCoordination ComplexesHeterocyclic Compounds, 3-RingindoleIndoleslatonduine Alatonduine BTubulin

Identifiers

PMID34995063
PMCPMC8790753
OpenAlexW4205719742

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.