Evidence map›Paper›PMID 34994860›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2022

Immunological and psychosocial functioning in parents of children with cancer.

Crystle-Joie Agbayani, Jo A Tucker, Edward L Nelson, Freddy Martinez, Haydee Cortes, Dina Khoury, Zeev N Kain, Carol Lin, Lilibeth Torno, Michelle A Fortier

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
5.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Impact of Pediatric Leukemia on Maternal Anxiety, Depression, Sleep Quality, and Physical Activity.Medical science monitor : international medical journal of experimental and clinical research · 2025
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Crystle-Joie AgbayaniUCI Center on Stress and Health, School of Medicine, University of California-Irvine, Irvine, CA, USA.
Jo A TuckerDepartment of Medicine, Division of Hematology Oncology, University of California-Irvine, Irvine, CA, USA.
Edward L NelsonDepartment of Medicine, Division of Hematology Oncology, University of California-Irvine, Irvine, CA, USA.
Freddy MartinezUCI Center on Stress and Health, School of Medicine, University of California-Irvine, Irvine, CA, USA.
Haydee CortesUCI Center on Stress and Health, School of Medicine, University of California-Irvine, Irvine, CA, USA.
Dina KhouryUCI Center on Stress and Health, School of Medicine, University of California-Irvine, Irvine, CA, USA.
Zeev N KainUCI Center on Stress and Health, School of Medicine, University of California-Irvine, Irvine, CA, USA.
Carol LinHyundai Cancer Institute, CHOC, Orange, CA, USA.
Lilibeth TornoHyundai Cancer Institute, CHOC, Orange, CA, USA.
Michelle A FortierUCI Center on Stress and Health, School of Medicine, University of California-Irvine, Irvine, CA, USA. mfortier@uci.edu.
University of California, Irvine · US

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Melanie Funes · 1994 to 2026
$57.9M
american cancer society 121296-PEP-Il-167-01-PCSMNCI NIH HHS P30 CA062203
6 · The paper itself

Abstract

purposeResearch has shown that parents of children with cancer exhibit an altered immune profile compared to parents of healthy children, reflective of increased susceptibility to illness. These parents are also at risk for poorer psychosocial outcomes and quality of life. The current study compares peripheral blood cell analyses and psychosocial self-reports from parents of children being treated for cancer (n = 21) to parents of healthy children (n = 30).

methodsA blood sample was drawn from parents to analyze immune profiles. Parents also completed the Perceived Stress Scale (PSS), Medical Outcomes Study Short Form-36 (MOS), and Patient-Reported Outcomes Measurement Information System Short Form v1.0 Emotional Distress-Anxiety 8a, and Emotional Distress-Depression 8a (PROMIS). Mann-Whitney U tests and independent samples t-tests were conducted to examine differences in outcomes between parent groups.

resultsParents of children with cancer exhibited higher monocyte percentages in their peripheral blood compared to peers with healthy children. Parents of children with cancer also reported poorer psychosocial outcomes: higher perceived stress, higher anxiety and depression symptoms, more role disability resulting from emotional problems, poorer general and mental health, and poorer social functioning.

conclusionThese findings support research that has shown a direct effect of chronic stress on the immune system. Symptoms reported by parents of children with cancer indicate unmet psychosocial needs that could potentially affect long-term health. Given the central role of parents in their children's cancer care, it is compelling to address and work to improve parent immunological and psychosocial well-being.

Indexed as

NeoplasmsQuality of LifeAnxietyHumansMental HealthParentsPsychosocial FunctioningParent caregiversPediatric oncologyPsychoneuroimmunologyQuality of life

Identifiers

PMID34994860
PMCPMC9833860
OpenAlexW4205932403

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.