Evidence map›Paper›PMID 34994746›Full record

ArticleBiomaterials science2022

PNJ scaffolds promote microenvironmental regulation of glioblastoma stem-like cell enrichment and radioresistance.

John M Heffernan, James B McNamara, Brent L Vernon, Shwetal Mehta, Rachael W Sirianni

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

John M HeffernanIvy Brain Tumor Center, Barrow Neurological Institute, 350 W Thomas Rd, Phoenix, AZ 85013, USA.
James B McNamaraIvy Brain Tumor Center, Barrow Neurological Institute, 350 W Thomas Rd, Phoenix, AZ 85013, USA.
Brent L VernonSchool of Biological and Health Systems Engineering, Arizona State University, PO Box 879709, Tempe, AZ 85287, USA.
Shwetal MehtaIvy Brain Tumor Center, Barrow Neurological Institute, 350 W Thomas Rd, Phoenix, AZ 85013, USA.
Rachael W SirianniIvy Brain Tumor Center, Barrow Neurological Institute, 350 W Thomas Rd, Phoenix, AZ 85013, USA.ORCID http://orcid.org/0000-0002-9196-0239

Funding

Intrathecal delivery of radiation sensitizing nanoparticles in pediatric neuro-oncologyR01HD099543 · NICHD · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SIRIANNI, RACHAEL W · 2019 to 2023
$3.5M
Targeting Leptomeningeal Metastasis in MedulloblastomaR01NS111292 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SIRIANNI, RACHAEL W · 2019 to 2024
$2.4M
Targeting Olig2 Co-regulators for Malignant Glioma TherapyR01NS088648 · NINDS · ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER · PI MEHTA, SHWETAL · 2015 to 2019
$1.7M
NICHD NIH HHS R01 HD099543NINDS NIH HHS R01 NS088648NINDS NIH HHS R01 NS111292
6 · The paper itself

Abstract

Glioblastoma (GBM) brain tumors contain a subpopulation of self-renewing multipotent Glioblastoma stem-like cells (GSCs) that are believed to drive the near inevitable recurrence of GBM. We previously engineered temperature responsive scaffolds based on the polymer poly(

Indexed as

Brain NeoplasmsGlioblastomaCell Line, TumorHumansNeoplastic Stem Cells

Identifiers

PMID34994746
PMCPMC8939461

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.