Evidence map›Paper›PMID 34994689›Full record

ArticleeLife2022

An intestinally secreted host factor promotes microsporidia invasion of

Hala Tamim El Jarkass, Calvin Mok, Michael R Schertzberg, Andrew G Fraser, Emily R Troemel, Aaron W Reinke

Abstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Review
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  4. Parasite defense covaries with reproductive timing, not with resistance.bioRxiv : the preprint server for biology · 2026
    Article
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  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hala Tamim El JarkassDepartment of Molecular Genetics, University of Toronto, Toronto, Canada.ORCID https://orcid.org/0000-0003-0118-5978
Calvin MokDepartment of Molecular Genetics, University of Toronto, Toronto, Canada.
Michael R SchertzbergThe Donnelly Centre, University of Toronto, Toronto, Canada.
Andrew G FraserDepartment of Molecular Genetics, University of Toronto, Toronto, Canada.ORCID https://orcid.org/0000-0001-9939-6014
Emily R TroemelDivision of Biological Sciences, University of California, San Diego, La Jolla, United States.ORCID https://orcid.org/0000-0003-2422-0473
Aaron W ReinkeDepartment of Molecular Genetics, University of Toronto, Toronto, Canada.ORCID https://orcid.org/0000-0001-7612-5342

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
The Intracellular Pathogen Response Triggers Defense Against Co-evolved PathogensR01GM114139 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Emily R Troemel · 2015 to 2026
$3.1M
Probing organismal proteostasis through the response to intracellular infectionR01AG052622 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Emily R Troemel · 2017 to 2026
$2.7M
A natural host model for microsporidia pathogenesis in the intestineR01AI087528 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TROEMEL, EMILY R · 2010 to 2014
$1.9M
Probing organismal proteostasis through the response to intracellular infectionR56AG052622 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TROEMEL, EMILY R · 2016 to 2016
$388k
CIHR 400784NIAID NIH HHS R01 AI087528NIA NIH HHS R01 AG052622NIA NIH HHS R56 AG052622NIGMS NIH HHS R01 GM114139NIH HHS P40 OD010440
6 · The paper itself

Abstract

Microsporidia are ubiquitous obligate intracellular pathogens of animals. These parasites often infect hosts through an oral route, but little is known about the function of host intestinal proteins that facilitate microsporidia invasion. To identify such factors necessary for infection by

Indexed as

Host-Pathogen InteractionsAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsIntestinesMicrosporidiaCaenorhabditis elegans ProteinsC. elegansevolutionary trade-offsinfectious diseasemicrobiologymicrosporidiaparasite invasionPseudomonas aeruginosa

Identifiers

PMID34994689
PMCPMC8806185

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.