Evidence map›Paper›PMID 34994688›Full record

ArticleeLife2022

Structural basis for cytoplasmic dynein-1 regulation by Lis1.

John P Gillies, Janice M Reimer, Eva P Karasmanis, Indrajit Lahiri, Zaw Min Htet, Andres E Leschziner, Samara L Reck-Peterson

Open access · goldAbstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 51 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. The mechanochemical cycle of reactive full-length human dynein 1.Nature structural & molecular biology · 2025
    Article
  6. Article
  7. Multiple steps of dynein activation by Lis1 visualized by cryo-EM.Nature structural & molecular biology · 2025
    Article
  8. Review
  9. Article
  10. Nde1 Promotes Lis1 Binding to Full-Length Autoinhibited Human Dynein-1.bioRxiv : the preprint server for biology · 2025
    Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Nde1 Promotes Lis1-Mediated Activation of Dynein.bioRxiv : the preprint server for biology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

John P Gillies *Department of Cellular and Molecular Medicine, University of California, San Diego, San Diego, United States.ORCID 0000-0001-9659-5579
Janice M Reimer *Department of Cellular and Molecular Medicine, University of California, San Diego, San Diego, United States.ORCID 0000-0002-2664-5523
Eva P Karasmanis *Department of Cellular and Molecular Medicine, University of California, San Diego, San Diego, United States.ORCID 0000-0002-0139-0210
Indrajit LahiriDepartment of Cellular and Molecular Medicine, University of California, San Diego, San Diego, United States.
Zaw Min HtetDepartment of Cellular and Molecular Medicine, University of California, San Diego, San Diego, United States.
Andres E LeschzinerDepartment of Cellular and Molecular Medicine, University of California, San Diego, San Diego, United States.ORCID 0000-0002-7732-7023
Samara L Reck-PetersonDepartment of Cellular and Molecular Medicine, University of California, San Diego, San Diego, United States.ORCID 0000-0002-1553-465X
University of California San Diego · USHoward Hughes Medical Institute · USIndian Institute of Science Education and Research Mohali · IN

Funding

MOLECULAR BIOPHYSICS TRAINING PROGRAMT32GM008326 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KOMIVES, ELIZABETH A. · 1989 to 2020
$7.5M
Mechanism of cytoskeletal transport and transcription-coupled DNA repairR35GM145296 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI Andres E Leschziner · 2022 to 2026
$3.5M
Regulation of Cytoplasmic DyneinR01GM107214 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LESCHZINER, ANDRES · 2014 to 2021
$3.1M
Mechanisms of microtubule-based transportR35GM141825 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI RECK-PETERSON, SAMARA L · 2021 to 2025
$1.9M
Howard Hughes Medical InstituteNIGMS NIH HHS R01 GM107214NIGMS NIH HHS R35 GM141825NIGMS NIH HHS R35 GM145296NIGMS NIH HHS T32 GM008326
6 · The paper itself

Abstract

The lissencephaly 1 gene,

Indexed as

Gene Expression Regulation1-Alkyl-2-acetylglycerophosphocholine EsteraseCytoplasmic DyneinsDyneinsMicrotubule-Associated ProteinsSaccharomyces cerevisiaeSaccharomyces cerevisiae Proteins1-Alkyl-2-acetylglycerophosphocholine EsteraseCytoplasmic DyneinsDyneinsMicrotubule-Associated ProteinsPAFAH1B1 protein, S cerevisiaeSaccharomyces cerevisiae ProteinsBicD2cell biologydynactindyneinhook3humanLis1molecular biophysicsS. cerevisiaestructural biology

Identifiers

PMID34994688
PMCPMC8824474
OpenAlexW4225665913

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.