ArticleJournal of veterinary internal medicine2022
Randomized field trial comparing the efficacy of florfenicol and oxytetracycline in a natural outbreak of calf pneumonia using lung reaeration as a cure criterion.
Article in Journal of veterinary internal medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Efficacy of non-steroidal anti-inflammatory drug (NSAID) treatment for bovine respiratory disease: a systematic review and meta-analysis for the European Network for Optimization of Antimicrobial Therapy guidelines.Open research Europe · 2026Pooled it
- Article
- Effects of an optimized dairy calf-rearing protocol on performance and health in the subsequent fattening period on Swiss veal farms.Veterinary and animal science · 2026Article
- Use of Ultrasonography for the Evaluation of Lung Lesions in Lambs with Respiratory Complex.Animals : an open access journal from MDPI · 2025Article
- An on-farm observational study on the prevalence and associated factors of bacteremia in preweaned dairy calves diagnosed with bronchopneumonia by thoracic ultrasonography.BMC veterinary research · 2025Article
- Development and Progression of Bovine Respiratory Disease Measured Using Clinical Respiratory Scoring and Thoracic Ultrasonography in Preweaned Calves on Dairy Farms in the United Kingdom: A Prospective Cohort Study.Animals : an open access journal from MDPI · 2025Article
- Thoracic Ultrasound in Cattle: Methods, Diagnostics, and Prognostics.Veterinary sciences · 2025Review
- The diagnostic utility of thoracic ultrasonography in sheep and goats with contagious caprine pleuropneumonia.Frontiers in veterinary science · 2025Review
- Bovine Respiratory Disease in Veal Calves: Benefits Associated with Its Early Detection by Lung Ultrasonography and Its Prompt Treatment with a Single Dose of a Fixed Combination of Florfenicol and Meloxicam.Animals : an open access journal from MDPI · 2024Article
- Cross-sectional study: can endogenous procalcitonin differentiate between healthy and bovine respiratory disease-affected preweaned dairy calves?The veterinary quarterly · 2024Article
- Literature Review of the Principal Diagnostic Tests to Detect Bovine Respiratory Disease in Pre-Weaned Dairy and Veal Calves.Animals : an open access journal from MDPI · 2024Review
- Determination of pharmacokinetic-pharmacodynamic cutoff values of oxytetracycline in calves and adult cattle using population pharmacokinetic modeling.Frontiers in microbiology · 2024Article
- Investigation of the relationship between pulmonary lesions based on lung ultrasound and respiratory clinical signs in foals with suspected pulmonary rhodococcosis.Scientific reports · 2023Article
- Sepsis and survival in critically ill calves: Risk factors and antimicrobial use.Journal of veterinary internal medicine · 2023Article
- Randomized field trial comparing the efficacy of florfenicol and oxytetracycline in a natural outbreak of calf pneumonia using lung reaeration as a cure criterion.Journal of veterinary internal medicine · 2022Article
- Article
- Thoracic Ultrasonography in Calves: A Narrative Review of Techniques and Reporting Practices.Journal of veterinary internal medicineReview
- Association of Lung Consolidation Depth With Pathogens Isolated From Bronchoalveolar Lavage Fluid in Calves With Clinical Signs of Respiratory Disease.Journal of veterinary internal medicineArticle
- Echocardiographic Changes Related to Pulmonary Hypertension in Preweaned Dairy Calves With Bronchopneumonia: A Case-Control Study in Commercial Dairy Farms.Journal of veterinary internal medicineArticle
- Blood gases, acid-base, and metabolic alterations in calves with bronchopneumonia diagnosed via clinical signs and thoracic ultrasonography: A cross-sectional study.Journal of veterinary internal medicineArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundRespiratory infections are the main indication for antimicrobial use in calves. Optimal treatment duration currently is unknown, but shorter duration would likely decrease selection for antimicrobial resistance. HYPOTHESIS/
objectivesDetermine differences in cure rate and healing time between animals treated with florfenicol and oxytetracycline in a natural outbreak of respiratory disease using reaeration observed on thoracic ultrasound examination as healing criterion. ANIMALS: Commercial farm housing 130, 3 to 9 month old Belgian blue beef calves.
methodsRandomized clinical trial during an outbreak of respiratory disease. Metaphylactic treatment was initiated, randomly treating animals with either florfenicol or oxytetracycline. Ultrasonographic follow-up was done the first day and every other day for a 14-day period. At the individual animal level, treatment was discontinued when reaeration of the lungs occurred. Differences in cure rate and healing time were determined.
resultsOf the 130 animals studied, 67.7% developed a lung consolidation ≥0.5 cm. The mean ultrasonographic healing time was 2.5 days in the florfenicol group compared to 3.1 days in the oxytetracycline group (P = .04). After single treatment, 80.6% and 60.3% had no consolidations in the florfenicol and oxytetracycline groups, respectively (P = .01). A Mycoplasma bovis strain was genetically and phenotypically determined to be susceptible to both antimicrobials. CONCLUSIONS AND CLINICAL IMPORTANCE: Ultrasonographic lung reaeration shows potential as a cure criterion to rationalize antimicrobial use for outbreaks of pneumonia. In our study, florfenicol resulted in a faster cure and higher reduction in antimicrobial usage than did oxytetracycline.
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Registered trials
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