ArticleeLife2022
Context-dependent relationships between locus coeruleus firing patterns and coordinated neural activity in the anterior cingulate cortex.
Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 66 citations in OpenAlex.
- The impact of transcutaneous vagus nerve stimulation on anterior cingulate cortex activity in a cognitive control task.Psychophysiology · 2025Trial
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- Task-irrelevant stimuli robustly drive phasic pupil-linked arousal but only weakly affect memory formation.Scientific reports · 2026Article
- Interpretable abstractions of artificial neural networks predict behavior and neural activity during human information gathering.Nature neuroscience · 2026Article
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- Brain-wide arousal signals are segregated from movement planning in the superior colliculus of the macaque.eLife · 2026Article
- The Pupil-Brain System at Rest: Spontaneous Pupil Fluctuations as Markers of Neuromodulatory and Network Dynamics.Psychophysiology · 2026Review
- Cognitive Vergence and Pupillary Responses as Functional Oculomotor Signatures to Differentiate AT(N) Biological Profiles.bioRxiv : the preprint server for biology · 2026Article
- Cognitive Vergence and Pupil Response During Oddball Task are Associated With Alzheimer's Disease Cerebrospinal Fluid Neurodegenerative Biomarkers.bioRxiv : the preprint server for biology · 2026Article
- Pupillary responses to the glare illusion in normal pressure hydrocephalus: insights into network dysfunction and neurodegenerative comorbidities.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- The role of the locus coeruleus in eye movements during perceptual decision making.bioRxiv : the preprint server for biology · 2026Article
- Sensory adaptation supports flexible evidence accumulation during perceptual decision making.bioRxiv : the preprint server for biology · 2026Article
- Sound-evoked pupil dilation quantifies misophonic symptoms.PloS one · 2026Article
- Noradrenergic tuning of arousal is coupled to movement transitions.Cell reports · 2025Article
- Eye movement evidence for locus coeruleus-noradrenaline system contributions to age differences in attention.Psychology and aging · 2025Article
- Maternal separation disrupts noradrenergic control of adult coping behaviors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Adaptive arousal regulation: Pharmacologically shifting the peak of the Yerkes-Dodson curve by catecholaminergic enhancement of arousal.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Sex and Genetic Differences in Behavioral Engagement of Crossed High Alcohol-Preferring and Low Alcohol-Preferring Mice.Genes, brain, and behavior · 2025Article
- Saccade, pupil, and blink abnormalities in prodromal and manifest alpha-synucleinopathies.Journal of Parkinson's disease · 2025Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Ascending neuromodulatory projections from the locus coeruleus (LC) affect cortical neural networks via the release of norepinephrine (NE). However, the exact nature of these neuromodulatory effects on neural activity patterns in vivo is not well understood. Here, we show that in awake monkeys, LC activation is associated with changes in coordinated activity patterns in the anterior cingulate cortex (ACC). These relationships, which are largely independent of changes in firing rates of individual ACC neurons, depend on the type of LC activation: ACC pairwise correlations tend to be reduced when ongoing (baseline) LC activity increases but enhanced when external events evoke transient LC responses. Both relationships covary with pupil changes that reflect LC activation and arousal. These results suggest that modulations of information processing that reflect changes in coordinated activity patterns in cortical networks can result partly from ongoing, context-dependent, arousal-related changes in activation of the LC-NE system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.