Evidence map›Paper›PMID 34994242›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2022

MRI evaluation of cerebral metabolic rate of oxygen (CMRO

Pei-Hsin Wu, Ana E Rodríguez-Soto, Andrew Wiemken, Erin K Englund, Zachary B Rodgers, Michael C Langham, Richard J Schwab, John A Detre, Wensheng Guo, Felix W Wehrli

Open access · greenAbstract read
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Observational
  3. Review
  4. Article
  5. Article
  6. Recent Advances in MR Imaging-based Quantification of Brain Oxygen Metabolism.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2024
    Review
  7. Article
  8. Superior sagittal sinus flow as a proxy for tracking global cerebral blood flow dynamics during wakefulness and sleep.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023
    Article
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Pei-Hsin WuDepartment of Radiology, 6572University of Pennsylvania, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0001-8413-3676
Ana E Rodríguez-SotoDepartment of Radiology, 6572University of Pennsylvania, University of Pennsylvania, Philadelphia, PA, USA.
Andrew WiemkenDivision of Sleep Medicine, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Erin K EnglundDepartment of Radiology, 6572University of Pennsylvania, University of Pennsylvania, Philadelphia, PA, USA.
Zachary B RodgersDepartment of Radiology, 6572University of Pennsylvania, University of Pennsylvania, Philadelphia, PA, USA.
Michael C LanghamDepartment of Radiology, 6572University of Pennsylvania, University of Pennsylvania, Philadelphia, PA, USA.
Richard J SchwabDivision of Sleep Medicine, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
John A DetreDepartment of Neurology, University of Pennsylvania, Philadelphia, PA, USA.
Wensheng GuoDepartment of Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA, USA.
Felix W WehrliDepartment of Radiology, 6572University of Pennsylvania, University of Pennsylvania, Philadelphia, PA, USA.
University of Pennsylvania · USNational Sun Yat-sen University · TW

Funding

Phenotypic Diversity in COVID-19UL1TR001878 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2016 to 2025
$102.4M
Training in Structural, Physiologic and Functional MRIT32EB020087 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI JAMES C GEE, Chamith Sudesh Rajapakse · 2016 to 2026
$2.1M
Neurometabolic Assessment of Obstructive Sleep Apnea by MRIR01HL122754 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI WEHRLI, FELIX W · 2015 to 2018
$1.7M
NCATS NIH HHS UL1 TR001878NHLBI NIH HHS R01 HL122754NIBIB NIH HHS T32 EB020087
6 · The paper itself

Abstract

Patients with obstructive sleep apnea (OSA) are at elevated risk of developing systemic vascular disease and cognitive dysfunction. Here, cerebral oxygen metabolism was assessed in patients with OSA by means of a magnetic resonance-based method involving simultaneous measurements of cerebral blood flow rate and venous oxygen saturation in the superior sagittal sinus for a period of 10 minutes at an effective temporal resolution of 1.3 seconds before, during, and after repeated 24-second breath-holds mimicking spontaneous apneas, yielding, along with pulse oximetry-derived arterial saturation, whole-brain CMRO

Indexed as

OxygenSleep Apnea, ObstructiveBrainBreath HoldingHumansMagnetic Resonance ImagingOxygenBrain oxygen metabolismcerebral blood floweffect of breath-hold challengeobstructive sleep apneaquantitative MRI

Identifiers

PMID34994242
PMCPMC9125486
OpenAlexW4206230136

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.