SynthesisThe Journal of international medical research2022
Comprehensive meta-analysis of associations between temperament and character traits in Cloninger's psychobiological theory and mental disorders.
Synthesis in The Journal of international medical research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Specificity of environmental risk factors for schizophrenia, bipolar disorders, and depressive disorders - umbrella review.Psychological medicine · 2025Pooled it
- A Meta-Analytic Review of the Associations of the Big Five Personality Traits with Subjective Poor Sleep Quality and Insomnia, and Meta-Regression of Some Potential Moderators.International journal of behavioral medicine · 2025Pooled it
- Resilience after adversity: an umbrella review of adversity protective factors and resilience-promoting interventions.Frontiers in psychiatry · 2024Pooled it
- Judgment behaviors differentiate depression from anxiety.Scientific reports · 2026Article
- [Embryonic origin of temperament: notochord and early signaling].Revista medica del Instituto Mexicano del Seguro Social · 2026Review
- Layered vulnerabilities in young adults with major depressive disorder: personality, coping, and cognition.Frontiers in psychiatry · 2026Article
- The role of the DSM-5 maladaptive personality traits in adherence to sleep hygiene behaviors and sleep duration.Scientific reports · 2025Article
- Associations between Cloninger's temperament and character traits and light preference.Frontiers in psychiatry · 2025Article
- A Meta-Analysis of the Structural Validity of Original and Brief Versions of the Personality Inventory for DSM-5 in Iran.Iranian journal of psychiatry · 2025Review
- Complex associations between anxiety, depression, and resilience in a college student sample: a network analysis.Frontiers in psychiatry · 2025Article
- Temperament and character traits and profiles: impact on bipolar disorder risk and onset age.Frontiers in psychiatry · 2025Article
- Gene expression networks regulated by human personality.Molecular psychiatry · 2024Review
- Meta-Analytic Review of Temperamental Correlates of the Five-Factor Model and Hierarchical Taxonomy of Psychopathology Domains.Indian journal of psychological medicine · 2024Review
- Personality traits in patients with multiple sclerosis: their association with nicotine dependence and polypharmacy.Therapeutic advances in neurological disorders · 2024Article
- Revised Temperament and Character Inventory factors predict neuropsychiatric symptoms and aging-related cognitive decline across 25 years.Frontiers in aging neuroscience · 2024Article
- A head-to-head comparison of eight unique personality systems in predicting somatization phenomenon.BMC psychiatry · 2023Article
- The influence of dopamine autoreceptors on temperament and addiction risk.Neuroscience and biobehavioral reviews · 2023Review
- Construct and criterion validity of the HiTOP spectra to predict dimensional and categorical somatization in a large non-western sample.Scientific reports · 2023Article
- Risk factors of disordered eating in adolescent girls from a community sample: a multidimensional approach.Consortium psychiatricum · 2023Article
- The Relationship between Character Traits and In Vivo Cerebral Serotonin Transporter Availability in Healthy Subjects: A High-Resolution PET Study with C-11 DASB.Pharmaceuticals (Basel, Switzerland) · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo explore the relationship between temperament and character traits in Cloninger's psychobiological theory and mental disorders.
resultsThe pooled effect sizes obtained from 149 studies showed that high harm avoidance (related to 22/24 diagnostic categories), low self-directedness (21/23), low cooperativeness (17/23), high self-transcendence (14/23), low reward dependence (11/24), high novelty-seeking (10/24), low novelty-seeking (7/24), high persistence (2/23), low persistence (2/23) and high reward dependence (2/24) were related to psychopathology.
conclusionsAll traits provided unique psychobiological tools for differential diagnosis of mental disorders. However, high harm avoidance and low self-directedness played a canonical role in psychopathology. Despite the study limitations, additional studies are warranted to evaluate the differential diagnoses suggested by the present model.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.