ArticleReproductive sciences (Thousand Oaks, Calif.)2022
Identification of Candidate Gene Signatures and Regulatory Networks in Endometriosis and its Related Infertility by Integrated Analysis.
Article in Reproductive sciences (Thousand Oaks, Calif.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The trial behind it
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Who cites it
8 citing papers in PubMed, 7 citations in OpenAlex.
- Ovarian Endometriosis and Adenomyosis-Relevance, Pathophysiology of Ectopic Endometrium and Impact on Dysfunction of Eutopic Endometrium: A Narrative Review.Biomedicines · 2026Review
- Long RNA profiles of endometrial extracellular vesicles provide new insights into the pathogenesis of ovarian endometriosis.BMC women's health · 2026Article
- Single-cell and spatially resolved omics reveal transcriptional and metabolic signatures of ovarian endometriomas.Nature communications · 2025Article
- Homeobox C6 is Up-Regulated and Affects the Pathogenesis of Endometriosis.Reproductive sciences (Thousand Oaks, Calif.) · 2025Article
- Examination of homozygosity runs and selection signatures in native goat breeds of Henan, China.BMC genomics · 2024Article
- Expression Profiles of Genes Related to Development and Progression of Endometriosis and Their Association with Paraben and Benzophenone Exposure.International journal of molecular sciences · 2023Article
- Genomic insights into the conservation and population genetics of two Chinese native goat breeds.Journal of animal science · 2022Article
- Gene expression analysis in endometriosis: Immunopathology insights, transcription factors and therapeutic targets.Frontiers in immunology · 2022Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endometriosis is a common gynecological disease associated with infertility, and it represents an economic burden worldwide. However, the molecular mechanisms underlying endometriosis development have not yet been fully elucidated. Here, we aimed to identify reliable key genes and the related regulatory network that may be involved in endometriosis. Differentially expressed genes (DEGs) were identified through integrated analysis of four expression datasets of endometriosis from Gene Expression Omnibus. Gene functional analysis and protein-protein interaction network construction were performed to reveal the potential function of DEGs. Subsequently, candidate hub genes were defined and validated in GSE105764 dataset, and the associated regulatory networks were constructed. Additionally, GSE120103 dataset was applied to identify the differential expression between the infertile and fertile groups of patients with stage IV endometriosis. Finally, real-time quantitative polymerase chain reaction analysis was performed to identify the differential expression of hub genes in the collected clinical specimens. Robust rank aggregation integrated analysis determined 158 DEGs. Epithelial cell differentiation was the most significantly enriched biological process, and leukocyte transendothelial migration was the most significantly enriched pathway. Eight hub genes including CLDN3, CLDN5, CLDN7, CLDN11, HOXC8, HOXC6, HOXB6, and HOXB7 were identified, and most of these were validated as abnormally expressed genes in both the infertile group and patients with endometriosis. Transcriptional factors and microRNAs related to these genes were identified. Altogether, our integrated analysis identified critical gene signatures, involved pathways, and regulatory networks, which could provide clinically significant insights into the molecular mechanisms underlying endometriosis and its related infertility.
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