Evidence map›Paper›PMID 34993903›Full record

ReviewCardiology and therapy2022

Coronary Microvascular Disease.

Ravi A Thakker, Jorge Rodriguez Lozano, Patricia Rodriguez Lozano, Afaq Motiwala, Umamahesh Rangasetty, Wissam Khalife, Khaled Chatila

Open access · goldAbstract readReview
In one paragraph

Review in Cardiology and therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Review
  6. Relationship Between Hyperinsulinemia and Coronary Microvascular Disease.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Ravi A ThakkerDepartment of Internal Medicine, University of Texas Medical Branch, Galveston, TX, 77550, USA. ravi.a.thakker@gmail.com.ORCID http://orcid.org/0000-0001-7214-3439
Jorge Rodriguez LozanoDivision of Cardiology, University of Texas Medical Branch, Galveston, TX, USA.
Patricia Rodriguez LozanoDivision of Cardiovascular Medicine, University of Virginia, Charlottesville, VA, USA.
Afaq MotiwalaDivision of Cardiology, University of Texas Medical Branch, Galveston, TX, USA.
Umamahesh RangasettyDivision of Cardiology, University of Texas Medical Branch, Galveston, TX, USA.
Wissam KhalifeDivision of Cardiology, University of Texas Medical Branch, Galveston, TX, USA.
Khaled ChatilaDivision of Cardiology, University of Texas Medical Branch, Galveston, TX, USA.
The University of Texas Medical Branch at Galveston · USUniversity of Virginia · US

Funding

Training in Cardiovascular Imaging ResearchT32EB003841 · NIBIB · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Jonathan R Lindner · 2004 to 2026
$4.4M
NIBIB NIH HHS T32 EB003841
6 · The paper itself

Abstract

Coronary microvascular disease or dysfunction (CMVD) has been associated with adverse cardiovascular outcomes. Despite a growing prevalence, guidelines on definitive treatment are lacking. Proposed mechanisms of endothelial dysfunction and resultant inflammation have been demonstrated as the underlying cause. Imaging modalities such as echocardiography, cardiac MRI, PET, and in some instances CT, have been shown to be useful in diagnosing CMVD mainly through assessment of coronary blood flow. Invasive measurements through thermodilution and pressure sensor-guided Doppler microcatheters have also been utilized. Treatment options are directed at targeting inflammatory pathways and angina. In our review, we highlight the current literature on the background of CMVD, diagnostic modalities, and management of this disease.

Indexed as

Coronary microvascular diseaseCoronary microvascular dysfunctionNon-obstructive coronary artery disease

Identifiers

PMID34993903
PMCPMC8933600
OpenAlexW4205802445

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.