ArticleClinical rheumatology2022
Analysis of children with Henoch-Schonlein purpura secondary to infection.
Article in Clinical rheumatology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 16 citations in OpenAlex.
- New epidemiological characteristics of childhood IgA vasculitis in the post-COVID-19 era: a single-center retrospective cohort study.Pediatric rheumatology online journal · 2026Article
- Demographic, Clinical, and Laboratory Characteristics of Pediatric IgA Vasculitis: A Retrospective Five-Year Single-Center Experience.Journal of clinical medicine · 2026Article
- A predictive model based on routine blood inflammatory markers for IgA vasculitis in children.Frontiers in pediatrics · 2026Article
- Effects of disease severity-based nursing intervention on immune function and IFN-γ, IL-6, and TNF-α for children with IgA vasculitis nephritis.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Serum IgE and IgA Levels in Pediatric Henoch-Schönlein Purpura: Clinical Characteristics and Immunological Correlations in the Context of Infectious Diseases-A Five-Year Retrospective Analysis.International journal of molecular sciences · 2025Article
- The Impact of Infectious Diseases on Clinical Characteristics and Immunological Correlations in Pediatric Henoch-Schönlein Purpura: A Five-Year Retrospective Study.Biomedicines · 2025Article
- Article
- Clinical prediction model for progression from henoch-schönlein purpura to nephritis in pediatric patients.American journal of translational research · 2024Article
- Immunoglobulin a vasculitis with testicular/epididymal involvement in children: A retrospective study of a ten-year period.Frontiers in pediatrics · 2023Article
- Mean platelet volume may not have a predictive value for renal involvement in Henoch-Schönlein purpura secondary to Mycoplasma pneumoniae infection.Clinical rheumatology · 2022Article
- Article
- Development and validation of a nomogram to predict recurrence in children with Henoch-Schönlein purpura.American journal of translational research · 2022Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesHenoch-Schonlein purpura (HSP) is the most common childhood vasculitis, infection is the most essential inducement. We hypothesized that infection could impact the blood routine characteristics and/or outcome of vasculitis. Thus, we aim to find the most common infectious agent in HSP patients and identify convenient indicators to predict renal involvement in HSP patients with infection.
methodWe conducted a retrospective study of 208 HSP children and 98 healthy children. Clinical parameters were compared in those cases.
resultsA total of 68.75% of patients were infected with various pathogens. The mean platelet volume (MPV) (P < 0.02) was lower in HSP patients with infection than patients without infection. Mycoplasma pneumoniae (MP) infection accounted for the largest proportion (45.77%). MPV in HSP nephritis (HSPN) group was lower than in HSP patients (excluded renal involvement) in patients with MP infection. Logistic regression analysis found that age and MPV were risk factors for the occurrence of MP-infected HSPN. The receiver operating characteristic curve (ROC) analysis showed that the combination of MPV with the onset age at the optimal cut-off point had 81% sensitivity in predicting whether HSP patients with MP infection would develop into HSPN.
conclusionsOur research revealed that MP was the most commonly infected pathogen of children's HSP. MPV was an essential predictor of nephritis in HSP patients with MP infection. This discovery can prompt clinical treatments as well as reduce costs. Key Points • Mycoplasma pneumoniae (MP) accounts for the largest proportion in HSP children with infection. • MPV can be used as a predictor for the development of MP-triggered HSP to HSPN.
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