Evidence map›Paper›PMID 34993582›Full record

Trial reportClinical neuroradiology2022

Association of Stent-Retriever Characteristics in Establishing Successful Reperfusion During Mechanical Thrombectomy : Results from the ESCAPE-NA1 Trial.

Petra Cimflova, Nishita Singh, Johanna M Ospel, Martha Marko, Nima Kashani, Arnuv Mayank, Ricardo Hanel, Diogo C Haussen, Aditya Bharatha, David Volders and 14 more

Abstract readClinical Trial
PubMed Publisher
In one paragraph

Trial report in Clinical neuroradiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Combined technique versus stent-retriever alone: Interaction analysis of angioarchitectural and technical features.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 11 institutions in 5 countries.

Petra CimflovaDepartment of Clinical Neurosciences, University of Calgary, Calgary, Canada.ORCID http://orcid.org/0000-0001-8058-383X
Nishita SinghDepartment of Clinical Neurosciences, University of Calgary, Calgary, Canada.ORCID http://orcid.org/0000-0003-3647-0904
Johanna M OspelDepartment of Clinical Neurosciences, University of Calgary, Calgary, Canada.ORCID http://orcid.org/0000-0003-0029-6764
Martha MarkoDepartment of Clinical Neurosciences, University of Calgary, Calgary, Canada.ORCID http://orcid.org/0000-0002-9063-0465
Nima KashaniDepartment of Clinical Neurosciences, University of Calgary, Calgary, Canada.ORCID http://orcid.org/0000-0002-9752-784X
Arnuv MayankDepartment of Clinical Neurosciences, University of Calgary, Calgary, Canada.
Ricardo HanelStroke and Cerebrovascular Center, Baptist Medical Center Jacksonville, Jacksonville, FL, USA.ORCID http://orcid.org/0000-0001-7195-5806
Diogo C HaussenDepartment of Neurology, Marcus Stroke and Neuroscience Center, Grady Memorial Hospital/Emory University, Atlanta, GA, USA.ORCID http://orcid.org/0000-0003-1884-2196
Aditya BharathaDivisions of Neuroradiology and Neurosurgery, St Michael's Hospital, Toronto, Canada.
David VoldersDepartment of Radiology, Dalhousie University, Halifax, NS, Canada.ORCID http://orcid.org/0000-0003-4074-8702
Manraj K S HeranDepartment of Radiology, Vancouver General Hospital, Vancouver, British Columbia, Canada.ORCID http://orcid.org/0000-0003-0040-6054
Alexandre Y PoppeCentre Hospitalier de l'Université de Montréal, Montreal, Canada.ORCID http://orcid.org/0000-0002-1419-2635
Brian van AdelDepartments of Surgery and Medicine, Division of Neurology, Neurosurgery and Diagnostic Imaging, McMaster University, Hamilton, Ontario, Canada.
Bijoy K MenonDepartment of Clinical Neurosciences, University of Calgary, Calgary, Canada.
Manish JoshiDepartment of Radiology, Cumming School of Medicine, University of Calgary, Calgary, Canada.
Andrew DemchukDepartment of Clinical Neurosciences, University of Calgary, Calgary, Canada.ORCID http://orcid.org/0000-0002-4930-7789
Ryan McTaggartWarren Alpert School of Medicine, Brown University, Providence, RI, USA.ORCID http://orcid.org/0000-0001-5853-5161
Raul G NogueiraDepartment of Neurology, Marcus Stroke and Neuroscience Center, Grady Memorial Hospital/Emory University, Atlanta, GA, USA.ORCID https://orcid.org/0000-0003-4532-153X
Jeremy L RempelUniversity of Alberta Hospital, Edmonton, AB, Canada.ORCID http://orcid.org/0000-0003-2324-8415
Charlotte ZernaDepartment of Clinical Neurosciences, University of Calgary, Calgary, Canada.ORCID http://orcid.org/0000-0001-5969-8990
Michael TymianskiNoNO, Toronto, ON, Canada.
Michael D HillDepartment of Clinical Neurosciences, University of Calgary, Calgary, Canada.
Mayank GoyalDepartment of Clinical Neurosciences, University of Calgary, Calgary, Canada.ORCID http://orcid.org/0000-0001-9060-2109
Mohammed A AlmekhlafiDepartment of Clinical Neurosciences, University of Calgary, Calgary, Canada. mohammed.almekhlafi1@ucalgary.ca.ORCID http://orcid.org/0000-0001-9550-8197
University of Calgary · CAGrady Memorial Hospital · USAlberta Hospital Edmonton · CABaptist Medical Center Jacksonville · USBrown University · USCentre Hospitalier de l’Université de Montréal · CADalhousie University · CAMcMaster University · CANoNO (Canada) · CASt. Michael's Hospital · CAVancouver General Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSuccessful reperfusion determines the treatment effect of endovascular thrombectomy. We evaluated stent-retriever characteristics and their relation to reperfusion in the ESCAPE-NA1 trial.

methodsIndependent re-scoring of reperfusion grade for each attempt was conducted. The following characteristics were evaluated: stent-retriever length and diameter, thrombus position within stent-retriever, bypass effect, deployment in the superior or inferior MCA trunk, use of balloon guide catheter and distal access catheter. Primary outcome was successful reperfusion defined as expanded thrombolysis in cerebral infarction (eTICI) 2b-3 per attempt. The secondary outcome was successful reperfusion eTICI 2b-3 after the first attempt. Separate regression models for each stent-retriever characteristic and an exploratory multivariable modeling to test the impact of all characteristics on successful reperfusion were built.

resultsOf 1105 patients in the trial, 809 with the stent-retriever use (1241 attempts) were included in the primary analysis. The stent-retriever was used as the first-line approach in 751 attempts. A successful attempt was associated with thrombus position within the proximal or middle third of the stent (OR 2.06; 95% CI: 1.24-3.40 and OR 1.92; 95% CI: 1.16-3.15 compared to the distal third respectively) and with bypass effect (OR 1.7; 95% CI: 1.07-2.72). Thrombus position within the proximal or middle third (OR 2.80; 95% CI: 1.47-5.35 and OR 2.05; 95% CI: 1.09-3.84, respectively) was associated with first-pass eTICI 2b-3 reperfusion. In the exploratory analysis accounting for all characteristics, bypass effect was the only independent predictor of eTICI 2b-3 reperfusion (OR 1.95; 95% CI: 1.10-3.46).

conclusionThe presence of bypass effect and thrombus positioning within the proximal and middle third of the stent-retriever were strongly associated with successful reperfusion.

Indexed as

Brain IschemiaStrokeThrombosisCerebral InfarctionHumansReperfusionRetrospective StudiesStentsThrombectomyTreatment OutcomeBypass effectDevice-thrombus interactionEndovascular treatmentIschemic strokeThrombus position within the stent-retriever

Identifiers

PMID34993582
OpenAlexW4206030080

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.