ReviewDiabetologia2022
Do gene-environment interactions have implications for the precision prevention of type 2 diabetes?
Review in Diabetologia, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Genetic basis of Asian diabetes.Journal of diabetes investigation · 2026Review
- Article
- Social and rural determinants of glycemic control in type 2 diabetes mellitus.The Indian journal of medical research · 2026Article
- Strategies for optimization of hypoglycemia rat models.Animal models and experimental medicine · 2025Review
- High-sensitivity c-reactive protein and cardiovascular disease risk assessment in a population of type 2 diabetes mellitus patients.BMC cardiovascular disorders · 2025Article
- The national and provincial prevalence and non-fatal burdens of diabetes in China from 2005 to 2023 with projections of prevalence to 2050.Military Medical Research · 2025Article
- The influence of hypertensive disorders of pregnancy on the development of long-term postpartum type 2 diabetes mellitus.Endocrine journal · 2025Article
- Comparison of polygenic risk scores for type 2 diabetes developed from different ancestry groups.npj metabolic health and disease · 2025Article
- Longitudinal association of cumulative risk factors in early life, genetic risk, and healthy lifestyles during adulthood with the risk of type 2 diabetes.BMC medicine · 2025Article
- Understanding and applying gene-environment interactions: a guide for nutrition professionals with an emphasis on integration in African research settings.Nutrition reviews · 2025Review
- How shared versus unshared parental contribution to child risk influences guilt responses.Journal of health psychology · 2024Article
- 1,25(OH)Endocrine · 2024Article
- Interaction effect between low birthweight and resistin gene rs1862513 variant on insulin resistance and type 2 diabetes mellitus in adulthood: Toon Genome Study.Journal of diabetes investigation · 2024Article
- Spontaneous Akt2 deficiency in a colony of NOD mice exhibiting early diabetes.Scientific reports · 2024Article
- Precision prevention in occupational health: a conceptual analysis and development of a unified understanding and an integrative framework.Frontiers in public health · 2024Article
- Immunological Imbalances Associated with Epileptic Seizures in Type 2 Diabetes Mellitus.Brain sciences · 2023Review
- Association ofGlobal medical genetics · 2023Article
- Vitamin D and ω-3 Polyunsaturated Fatty Acids towards a Personalized Nutrition of Youth Diabetes: A Narrative Lecture.Nutrients · 2022Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The past decades have seen a rapid global rise in the incidence of type 2 diabetes. This surge has been driven by diabetogenic environmental changes that may act together with a genetic predisposition to type 2 diabetes. It is possible that there is a synergistic gene-environment interaction, where the effects of the diabetogenic environment depend on the genetic predisposition to type 2 diabetes. Randomised trials have shown that it is possible to delay, or even prevent the development of type 2 diabetes in individuals at elevated risk through behavioural modification, focusing on weight loss, physical activity and diet. There is wide heterogeneity between individuals regarding the effectiveness of these interventions, which could, in part, be due to genetic differences. However, the studies of gene-environment interactions performed thus far suggest that behavioural modifications appear equally effective in reducing the incidence of type 2 diabetes from the stage of impaired glucose tolerance, regardless of the known underlying genetic predisposition. Recent studies suggest that there may be several subtypes of type 2 diabetes, which give new opportunities for gaining insight into gene-environment interactions. At present, the role of gene-environment interactions in the development of type 2 diabetes remains unclear. With many puzzle pieces missing in the general picture of type 2 diabetes development, the available evidence of gene-environment interactions is not ready for translation to individualised type 2 diabetes prevention based on genetic profiling.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.