ArticleInternational journal of epidemiology2022
Glycated haemoglobin (HbA1c) in mid-pregnancy and perinatal outcomes.
Article in International journal of epidemiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The effect of high-fibre diets on glycaemic control in women with diabetes in pregnancy: A systematic review and meta-analysis.Diabetic medicine : a journal of the British Diabetic Association · 2025Pooled it
- The impact of obesity on pregnancy outcomes in women with type 1 and type 2 diabetes across the NSW population: A retrospective cohort study.Diabetic medicine : a journal of the British Diabetic Association · 2026Article
- Hypertensive Disorders of Pregnancy, Preterm Delivery, and Infant Size: Which Mothers Have Highest Cardiovascular Disease Mortality?Paediatric and perinatal epidemiology · 2025Article
- Predictive Value of Second Trimester HbA1c for Adverse Perinatal Outcomes: A Comparative Study in Diabetic and Non-Diabetic Pregnancies.International journal of women's health · 2025Article
- MV-Flow imaging for evaluating the placental function of gestational diabetes mellitus.Frontiers in endocrinology · 2025Article
- Exposure to Low-Level Air Pollution and Hyperglycemia Markers during Pregnancy: A Repeated Measure Analysis.Environmental science & technology · 2024Article
- Post-load glucose is a stronger predictor of adverse pregnancy outcomes than first-trimester HbA1c in women without gestational diabetes.Journal of diabetes investigation · 2024Article
- Diabetes and pregnancy study (DAPSY): a 10-year single-center cohort study of pregnancies affected by diabetes.Archives of gynecology and obstetrics · 2024Article
- Early HbA1c Levels as a Predictor of Adverse Obstetric Outcomes: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2024Review
- Pregnancy History at 40 Years of Age as a Marker of Cardiovascular Risk.Journal of the American Heart Association · 2024Article
- Early to mid-pregnancy HbA1c levels and its association with adverse pregnancy outcomes in three low middle-income countries in Asia and Sub-Saharan Africa.BMC pregnancy and childbirth · 2024Article
- Trimester-specific reference intervals for hemoglobin A1c in non-diabetic pregnancy in a Chinese population.BMC pregnancy and childbirth · 2023Article
- Invited Commentary: Beyond Barker-Mothers Are the Ones at Risk.American journal of epidemiology · 2023Article
- Pre-pregnancy body mass index and glycated-hemoglobin with the risk of metabolic diseases in gestational diabetes: a prospective cohort study.Frontiers in endocrinology · 2023Article
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Authors and funding
8 authors.
Funding
Abstract
backgroundMaternal diabetes is a well-known risk factor for pregnancy complications. Possible links between long-term maternal blood sugar in the normal range and pregnancy complications are less well described.
methodsWe assayed glycated haemoglobin (HbA1c) in blood samples collected around the 18th week of pregnancy for 2937 singleton pregnancies in the Norwegian Mother, Father and Child Cohort Study (2000-09). Perinatal outcomes (gestational length, birthweight, birth length and head circumference, large-for-gestational age, small-for-gestational age, congenital malformations, preterm delivery and preeclampsia) were obtained from medical records. We tested associations using linear and log-binomial regression, adjusting for maternal age, body mass index (BMI) and smoking.
resultsSize at birth increased modestly but linearly with HbA1c. Birthweight rose 0.10 standard deviations [95% confidence interval (CI): 0.03, 0.16], for each 5-mmol/mol unit increase in HbA1c, corresponding to about 40 g at 40 weeks of gestation. Large-for-gestational age rose 23% (95% CI: 1%, 50%) per five-unit increase. Other pregnancy complications increased in non-linear fashion, with strongest associations within the top quartile of HbA1c (>35 mmol/mol or >5.4%). Per unit HbA1c within the top quartile, preterm delivery increased by 14% (95% CI: 1%, 31%), preeclampsia increased by 20% (95% CI: 5%, 37%) and gestational duration decreased by 0.7 days (95% CI: -1.0, -0.3).
conclusionsAmong women with no recorded diabetes, higher HbA1c levels at 18 gestational weeks were associated with important perinatal outcomes independent of mother's age, smoking or BMI.
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