Evidence map›Paper›PMID 34993496›Full record

ArticleHGG advances2022

Genetic Factors Associated with Prostate Cancer Conversion from Active Surveillance to Treatment.

Yu Jiang, Travis J Meyers, Adaeze A Emeka, Lauren Folgosa Cooley, Phillip R Cooper, Nicola Lancki, Irene Helenowski, Linda Kachuri, Daniel W Lin, Janet L Stanford and 87 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in HGG advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

97 authors at 20 institutions in 4 countries.

Yu JiangDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA 94158, USA.
Travis J MeyersDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA 94158, USA.
Adaeze A EmekaDepartment of Urology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Lauren Folgosa CooleyDepartment of Urology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Phillip R CooperDepartment of Urology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Nicola LanckiDivision of Biostatistics, Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Irene HelenowskiDivision of Biostatistics, Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Linda KachuriDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA 94158, USA.
Daniel W LinFred Hutchinson Cancer Research Center, Cancer Prevention Program, Public Health Sciences, Seattle, WA 98109, USA.
Janet L StanfordFred Hutchinson Cancer Research Center, Cancer Epidemiology Program, Public Health Sciences, Seattle, WA 98109, USA.
Lisa F NewcombFred Hutchinson Cancer Research Center, Cancer Prevention Program, Public Health Sciences, Seattle, WA 98109, USA.
Suzanne KolbFred Hutchinson Cancer Research Center, Cancer Epidemiology Program, Public Health Sciences, Seattle, WA 98109, USA.
Antonio FinelliDivision of Urology, Department of Surgery, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Neil E FleshnerDivision of Urology, Department of Surgery, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Maria KomisarenkoDivision of Urology, Department of Surgery, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
James A EasthamUrology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Behfar EhdaieUrology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Nicole BenfanteUrology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Christopher J LogothetisDepartments of Genitourinary Medical Oncology and Urology, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
Justin R GreggDepartments of Genitourinary Medical Oncology and Urology, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
Cherie A PerezDepartments of Genitourinary Medical Oncology and Urology, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
Sergio GarzaDepartments of Genitourinary Medical Oncology and Urology, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
Jeri KimDepartments of Genitourinary Medical Oncology and Urology, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
Leonard S MarksDepartment of Urology, David Geffen School of Medicine at UCLA, USA.
Merdie DelfinDepartment of Urology, David Geffen School of Medicine at UCLA, USA.
Danielle BarsaDepartment of Urology, David Geffen School of Medicine at UCLA, USA.
Danny VespriniOdette Cancer Centre, Sunnybrook Health and Sciences Centre, University of Toronto, Toronto, ON, Canada.
Laurence H KlotzOdette Cancer Centre, Sunnybrook Health and Sciences Centre, University of Toronto, Toronto, ON, Canada.
Andrew LoblawOdette Cancer Centre, Sunnybrook Health and Sciences Centre, University of Toronto, Toronto, ON, Canada.
Alexandre MamedovOdette Cancer Centre, Sunnybrook Health and Sciences Centre, University of Toronto, Toronto, ON, Canada.
S Larry GoldenbergDepartment of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada.
Celestia S HiganoDepartment of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada.
Maria SpillaneDepartment of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada.
Eugenia WuDepartment of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada.
H Ballentine CarterBrady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Christian P PavlovichBrady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Mufaddal MamawalaBrady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Tricia LandisBrady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Peter R CarrollDepartment of Urology, University of California, San Francisco, San Francisco, CA, USA.
June M ChanDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA 94158, USA.
Matthew R CooperbergDepartment of Urology, University of California, San Francisco, San Francisco, CA, USA.
Janet E CowanDepartment of Urology, University of California, San Francisco, San Francisco, CA, USA.
Todd M MorganDepartment of Urology, University of Michigan, Ann Arbor, MI, USA.
Javed SiddiquiDepartment of Pathology, University of Michigan, Ann Arbor, MI, USA.
Rabia MartinDepartment of Pathology, University of Michigan, Ann Arbor, MI, USA.
Eric A KleinGlickman Urological and Kidney Institute, Cleveland Clinic Lerner College of Medicine, Cleveland Clinic, USA.
Karen BrittainGlickman Urological and Kidney Institute, Cleveland Clinic Lerner College of Medicine, Cleveland Clinic, USA.
Paige GotwaldGlickman Urological and Kidney Institute, Cleveland Clinic Lerner College of Medicine, Cleveland Clinic, USA.
Daniel A BarocasDepartment of Urology, Vanderbilt University Medical Center, Nashville, TN, USA.
Jeremiah R DallmerDepartment of Urology, Vanderbilt University Medical Center, Nashville, TN, USA.
Jennifer B GordetskyDepartment of Urology, Vanderbilt University Medical Center, Nashville, TN, USA.
Pam SteeleDepartment of Urology, Vanderbilt University Medical Center, Nashville, TN, USA.
Shilajit D KunduDepartment of Urology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Jazmine StockdaleDepartment of Urology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Monique J RoobolDepartment of Urology, Erasmus Cancer Institute, Erasmus University Medical Center, Rotterdam, the Netherlands.
Lionne D F VenderbosDepartment of Urology, Erasmus Cancer Institute, Erasmus University Medical Center, Rotterdam, the Netherlands.
Martin G SandaDepartment of Urology, Emory University School of Medicine, Atlanta, GA, USA.
Rebecca ArnoldDepartment of Urology, Emory University School of Medicine, Atlanta, GA, USA.
Dattatraya PatilDepartment of Urology, Emory University School of Medicine, Atlanta, GA, USA.
Christopher P EvansDepartment of Urologic Surgery, University of California, Davis Medical Center, Sacramento, CA, USA.
Marc A Dall'EraDepartment of Urologic Surgery, University of California, Davis Medical Center, Sacramento, CA, USA.
Anjali VijDepartment of Urologic Surgery, University of California, Davis Medical Center, Sacramento, CA, USA.
Anthony J CostelloDepartment of Urology, Royal Melbourne Hospital and University of Melbourne, Australia.
Ken ChowDepartment of Urology, Royal Melbourne Hospital and University of Melbourne, Australia.
Niall M CorcoranDepartment of Urology, Royal Melbourne Hospital and University of Melbourne, Australia.
Soroush Rais-BahramiDepartment of Urology, University of Alabama at Birmingham, Birmingham, AL, USA.
Courtney PharesDepartment of Urology, University of Alabama at Birmingham, Birmingham, AL, USA.
Douglas S ScherrDepartment of Urology, Weill Cornell Medicine, New York-Presbyterian Hospital, New York, NY, USA.
Thomas FlynnDepartment of Urology, Weill Cornell Medicine, New York-Presbyterian Hospital, New York, NY, USA.
R Jeffrey KarnesMayo Clinic Department of Urology, Rochester, MN, USA.
Michael KochDepartment of Urology, Indiana University School of Medicine, Indianapolis, IN, USA.
Courtney Rose DhondtDepartment of Urology, Indiana University School of Medicine, Indianapolis, IN, USA.
Joel B NelsonDepartment of Urology, University of Pittsburgh School of Medicine, PA, USA.
Dawn McBrideDepartment of Urology, University of Pittsburgh School of Medicine, PA, USA.
Michael S CooksonDepartment of Urology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Kelly L StrattonDepartment of Urology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Stephen FarriesterDepartment of Urology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Erin HemkenDepartment of Urology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Walter M StadlerUniversity of Chicago Comprehensive Cancer Center, Chicago, IL, USA.
Tuula PeraUniversity of Chicago Comprehensive Cancer Center, Chicago, IL, USA.
Deimante BanionyteUniversity of Chicago Comprehensive Cancer Center, Chicago, IL, USA.
Fernando J BiancoUrological Research Network, Miami Lakes, FL, USA.
Isabel H LopezUrological Research Network, Miami Lakes, FL, USA.
Stacy LoebDepartments of Urology and Population Health, New York University Langone Health and Manhattan Veterans Affairs Medical Center, New York, NY, USA.
Samir S TanejaDepartments of Urology and Population Health, New York University Langone Health and Manhattan Veterans Affairs Medical Center, New York, NY, USA.
Nataliya ByrneDepartments of Urology and Population Health, New York University Langone Health and Manhattan Veterans Affairs Medical Center, New York, NY, USA.
Christopher L AmlingDepartment of Urology, Oregon Health and Science University, Portland, OR, USA.
Ann MartinezDepartment of Urology, Oregon Health and Science University, Portland, OR, USA.
Luc BoileauDepartment of Urology, Oregon Health and Science University, Portland, OR, USA.
Franklin D GaylisGenesis Healthcare Partners, Department of Urology, University of California, San Diego, CA, USA.
Jacqueline PetkewiczDivision of Urology, NorthShore University Health System, Evanston, IL, USA.
Nicholas KirwenDivision of Urology, NorthShore University Health System, Evanston, IL, USA.
Brian T HelfandDivision of Urology, NorthShore University Health System, Evanston, IL, USA.
Jianfeng XuDivision of Urology, NorthShore University Health System, Evanston, IL, USA.
Denise M ScholtensDivision of Biostatistics, Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
William J CatalonaDepartment of Urology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
John S WitteDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA 94158, USA.
Northwestern University · USUniversity of California, San Francisco · USThe University of Texas MD Anderson Cancer Center · USUniversity of Washington · USJohns Hopkins University · USNorthShore University HealthSystem · USSunnybrook Health Science Centre · CAUniversity Health Network · CAUniversity of Oklahoma Health Sciences Center · USCleveland Clinic Lerner College of Medicine · USEmory University · USMemorial Sloan Kettering Cancer Center · USNYU Langone Health · USOregon Health & Science University · USThe Royal Melbourne Hospital · AUUniversity of British Columbia · CAUniversity of California Davis Medical Center · USUniversity of California, Los Angeles · USUniversity of Chicago · USUniversity of Michigan · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
TRANSCRIPTOME AND PROTEOME STRATIFICATION OF PROSTATE ADENOCARCINOMA PHENOTYPESP50CA097186 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI PETER S NELSON · 2002 to 2026
$58.1M
The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
Tissue/InformaticsP50CA186786 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Ganesh S Palapattu · 2014 to 2026
$27.6M
Targeting FOXA1-downstream pathways: a novel therapeutic strategy for castration-resistant prostate cancerP50CA180995 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ABDULKADIR, SARKI A., HUSSAIN, MAHA H · 2015 to 2025
$19.9M
Prostate Cancer Biomarker and Imaging Validation Alliance: Emory University, University of Alabama Birmingham, and University of Texas SouthwesternU01CA113913 · NCI · EMORY UNIVERSITY · PI Martin G. Sanda · 2005 to 2026
$16.4M
Prostate cancer Active Surveillance Study (PASS) Cohort: Infrastructure Support for Cancer ResearchU01CA224255 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI LIN, DANIEL W. · 2019 to 2023
$6.7M
Biopsy Tracking and MRI Fusion to Enhance Imaging of Cancer Within the ProstateR01CA158627 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MARKS, LEONARD STEPHEN · 2011 to 2013
$1.4M
Prospective Assessment of Image Registration for the Diagnosis of Prostate CancerR01CA195505 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MARKS, LEONARD STEPHEN · 2015 to 2016
$705k
Aggressive Prostate Cancer: Linking Epigenomics and Genetics for PreventionK05CA175147 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI STANFORD, JANET L · 2014 to 2018
$445k
NCATS NIH HHS UL1 TR000445NCI NIH HHS K05 CA175147NCI NIH HHS P30 CA008748NCI NIH HHS P50 CA097186NCI NIH HHS P50 CA180995NCI NIH HHS P50 CA186786NCI NIH HHS R01 CA158627NCI NIH HHS R01 CA195505NCI NIH HHS U01 CA113913NCI NIH HHS U01 CA224255NHLBI NIH HHS HHSN268201700006C
6 · The paper itself

Abstract

Men diagnosed with low-risk prostate cancer (PC) are increasingly electing active surveillance (AS) as their initial management strategy. While this may reduce the side effects of treatment for prostate cancer, many men on AS eventually convert to active treatment. PC is one of the most heritable cancers, and genetic factors that predispose to aggressive tumors may help distinguish men who are more likely to discontinue AS. To investigate this, we undertook a multi-institutional genome-wide association study (GWAS) of 5,222 PC patients and 1,139 other patients from replication cohorts, all of whom initially elected AS and were followed over time for the potential outcome of conversion from AS to active treatment. In the GWAS we detected 18 variants associated with conversion, 15 of which were not previously associated with PC risk. With a transcriptome-wide association study (TWAS), we found two genes associated with conversion (

Indexed as

geneticsgenome-wide association studyprostateprostatic neoplasms

Identifiers

PMID34993496
PMCPMC8725988
OpenAlexW3215295275

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.