Evidence map›Paper›PMID 34993486›Full record

ArticleEuropean heart journal. Digital health2021

Detecting cardiomyopathies in pregnancy and the postpartum period with an electrocardiogram-based deep learning model.

Demilade A Adedinsewo, Patrick W Johnson, Erika J Douglass, Itzhak Zachi Attia, Sabrina D Phillips, Rohan M Goswami, Mohamad H Yamani, Heidi M Connolly, Carl H Rose, Emily E Sharpe and 5 more

Open access · goldAbstract read
In one paragraph

Article in European heart journal. Digital health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 40 citations in OpenAlex.

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  10. Adopting artificial intelligence in cardiovascular medicine: a scoping review.Hypertension research : official journal of the Japanese Society of Hypertension · 2024
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  14. BMJ medicine · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Demilade A AdedinsewoDepartment of Cardiovascular Medicine, Mayo Clinic, 4500 San Pablo Rd, Jacksonville, FL 32224, USA.ORCID https://orcid.org/0000-0002-8629-2029
Patrick W JohnsonDepartment of Quantitative Health Sciences, Mayo Clinic, 4500 San Pablo Rd, Jacksonville, FL 32224, USA.ORCID https://orcid.org/0000-0001-8365-1375
Erika J DouglassDepartment of Cardiovascular Medicine, Mayo Clinic, 4500 San Pablo Rd, Jacksonville, FL 32224, USA.
Itzhak Zachi AttiaDepartment of Cardiovascular Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA.
Sabrina D PhillipsDepartment of Cardiovascular Medicine, Mayo Clinic, 4500 San Pablo Rd, Jacksonville, FL 32224, USA.ORCID https://orcid.org/0000-0003-4577-9882
Rohan M GoswamiDepartment of Transplant Medicine, Mayo Clinic, 4500 San Pablo Rd, Jacksonville, FL 32224, USA.
Mohamad H YamaniDepartment of Cardiovascular Medicine, Mayo Clinic, 4500 San Pablo Rd, Jacksonville, FL 32224, USA.ORCID https://orcid.org/0000-0002-3567-8773
Heidi M ConnollyDepartment of Cardiovascular Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA.
Carl H RoseDepartment of Maternal and Fetal Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA.
Emily E SharpeDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA.ORCID https://orcid.org/0000-0003-4232-0718
Lori BlauwetDepartment of Cardiovascular Diseases, Olmsted Medical Center, 210 Ninth Street SE Rochester, MN 55904, USA.
Francisco Lopez-JimenezDepartment of Cardiovascular Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA.ORCID https://orcid.org/0000-0001-5788-9734
Paul A FriedmanDepartment of Cardiovascular Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA.
Rickey E CarterDepartment of Quantitative Health Sciences, Mayo Clinic, 4500 San Pablo Rd, Jacksonville, FL 32224, USA.ORCID https://orcid.org/0000-0002-0818-273X
Peter A NoseworthyDepartment of Cardiovascular Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA.
Mayo Clinic · USMayo Clinic in Florida · USOlmsted Medical Center · US

Funding

Mayo Clinic Interdisciplinary Women's Health Research ProgramK12HD065987 · NICHD · MAYO CLINIC ROCHESTER · PI KANTARCI, KEJAL · 2010 to 2023
$6.7M
NICHD NIH HHS K12 HD065987
6 · The paper itself

Abstract

aimsCardiovascular disease is a major threat to maternal health, with cardiomyopathy being among the most common acquired cardiovascular diseases during pregnancy and the postpartum period. The aim of our study was to evaluate the effectiveness of an electrocardiogram (ECG)-based deep learning model in identifying cardiomyopathy during pregnancy and the postpartum period. METHODS AND

resultsWe used an ECG-based deep learning model to detect cardiomyopathy in a cohort of women who were pregnant or in the postpartum period seen at Mayo Clinic. Model performance was evaluated using the area under the receiver operating characteristic curve (AUC), accuracy, sensitivity, and specificity. We compared the diagnostic probabilities of the deep learning model with natriuretic peptides and a multivariable model consisting of demographic and clinical parameters. The study cohort included 1807 women; 7%, 10%, and 13% had left ventricular ejection fraction (LVEF) of 35% or less, <45%, and <50%, respectively. The ECG-based deep learning model identified cardiomyopathy with AUCs of 0.92 (LVEF ≤ 35%), 0.89 (LVEF < 45%), and 0.87 (LVEF < 50%). For LVEF of 35% or less, AUC was higher in Black (0.95) and Hispanic (0.98) women compared to White (0.91). Natriuretic peptides and the multivariable model had AUCs of 0.85 to 0.86 and 0.72, respectively.

conclusionsAn ECG-based deep learning model effectively identifies cardiomyopathy during pregnancy and the postpartum period and outperforms natriuretic peptides and traditional clinical parameters with the potential to become a powerful initial screening tool for cardiomyopathy in the obstetric care setting.

Indexed as

Artificial intelligenceCardiomyopathyECGHeart failurePeripartumPregnancy

Identifiers

PMID34993486
PMCPMC8715757
OpenAlexW3196785578

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.