Evidence map›Paper›PMID 34993451›Full record

ReviewCJC open2021

Sex, Race, and Age Differences in Cardiovascular Outcomes in Implantable Cardioverter-Defibrillator Randomized Controlled Trials: A Systematic Review and Meta-analysis.

Mohammad K Syed, Hassan I Sheikh, Bradley McKay, Nicholas Tseng, Maureen Pakosh, Jessica E Caterini, Abhinav Sharma, Tracey J F Colella, Kaja M Konieczny, Kim A Connelly and 4 more

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in CJC open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 10 institutions in 2 countries.

Mohammad K SyedFaculty of Health Sciences, Ontario Tech University, Oshawa, Ontario, Canada.
Hassan I SheikhFaculty of Health Sciences, Ontario Tech University, Oshawa, Ontario, Canada.
Bradley McKayFaculty of Health Sciences, Ontario Tech University, Oshawa, Ontario, Canada.
Nicholas TsengFaculty of Biomedical Sciences, University of Waterloo, Waterloo, Ontario, Canada.
Maureen PakoshLibrary & Information Services, University Health Network, Toronto, Ontario, Canada.
Jessica E CateriniQueen's University Medical School, Kingston, Ontario, Canada.
Abhinav SharmaDepartment of Medicine, McGill University Health Centre, Montreal, Quebec, Canada.
Tracey J F ColellaKITE, Toronto Rehabilitation Institute, University Health Network, Toronto, Ontario, Canada.
Kaja M KoniecznyDepartment of Cardiology, St Michael's Hospital, Toronto, Ontario, Canada.
Kim A ConnellyDepartment of Cardiology, St Michael's Hospital, Toronto, Ontario, Canada.
Michelle M GrahamDepartment of Medicine, University of Alberta, Edmonton, Alberta, Canada.
Michael McDonaldDivision of Cardiology, Peter Munk Cardiac Centre, University Health Network, Toronto, Ontario, Canada.
Laura BanksFaculty of Health Sciences, Ontario Tech University, Oshawa, Ontario, Canada.
Varinder Kaur RandhawaDepartment of Cardiovascular Medicine, Heart, Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, Ohio, USA.
University of Ontario Institute of Technology · CASt. Michael's Hospital · CAUniversity Health Network · CACleveland Clinic · USMcGill University Health Centre · CAQueen's University · CAToronto Rehabilitation Institute · CAUniversity of Alberta · CAUniversity of Toronto · CAUniversity of Waterloo · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundData are limited regarding the use of implantable cardioverter-defibrillators (ICDs) in diverse populations. This study explores cardiovascular (CV) outcomes and mortality from ICD randomized controlled trials (RCTs), by sex, race, and age.

methodsFive electronic databases (PubMed, Emcare, Embase, MEDLINE, and Cumulative Index to Nursing & Allied Health Literature CINAHL) were searched for dates from their inception to July 12, 2021, for RCTs of ICD therapy in adult patients. Data were analyzed for clinical outcomes, including all-cause or CV death, and heart failure hospitalization (HFH).

resultsAmong 5 RCTs (mean age: 63 years; 78% male; 76% White) with moderate overall risk of bias, clinical outcomes in patients with an ICD (n = 3260) vs a control group (n = 3685) were compared. No between-group sex differences were observed for all-cause death (odds ratio [OR] 0.86,

conclusionsOutcomes data are sparse, by sex, race, and age, in current RCTs evaluating ICD therapy. Although ICD patient outcomes did not significantly differ by sex or race, improved data analyses and reporting are needed to determine the relationship between these sociocultural factors and clinical outcomes among distinct ICD patient cohorts.

Identifiers

PMID34993451
PMCPMC8712708
OpenAlexW3202107667

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.