Evidence map›Paper›PMID 34993349›Full record

ArticleBMJ open ophthalmology2021

Correlation of features on OCT with visual acuity and Gass lesion type in Best vitelliform macular dystrophy.

Razek G Coussa, Christopher R Fortenbach, D Brice Critser, Malia M Collins, Budd A Tucker, Robert F Mullins, Elliott H Sohn, Edwin M Stone, Ian C Han

Open access · goldAbstract read
In one paragraph

Article in BMJ open ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Observational
  3. Review
  4. Review
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Razek G CoussaDepartment of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa, USA.
Christopher R FortenbachDepartment of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa, USA.
D Brice CritserDepartment of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa, USA.
Malia M CollinsDepartment of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa, USA.
Budd A TuckerDepartment of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa, USA.
Robert F MullinsDepartment of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa, USA.
Elliott H SohnDepartment of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa, USA.
Edwin M StoneDepartment of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa, USA.
Ian C HanDepartment of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa, USA.ORCID 0000-0002-2371-727X
University of Iowa · US

Funding

Stem Cell and Organoid CoreP30EY025580 · NEI · UNIVERSITY OF IOWA · PI Budd A Tucker · 2016 to 2026
$6.9M
Disease Mechanisms in Best DiseaseR01EY024588 · NEI · UNIVERSITY OF IOWA · PI GAMM, DAVID M, MULLINS, ROBERT FOSTER · 2015 to 2018
$2.0M
Choroidal Disease Mechanisms in AMDR01EY026547 · NEI · UNIVERSITY OF IOWA · PI SOHN, ELLIOTT H · 2016 to 2020
$1.9M
NEI NIH HHS P30 EY025580NEI NIH HHS R01 EY024588NEI NIH HHS R01 EY026547
6 · The paper itself

Abstract

objectiveTo correlate structural features seen on optical coherence tomography (OCT) with best-corrected visual acuity (BCVA) and Gass lesion type in patients with Best vitelliform macular dystrophy (BVMD). METHODS AND ANALYSIS: This is a retrospective case series of consecutive patients with molecularly confirmed

results95 eyes from 48 patients (mean age 38.9 years, range 4-87) were included. The presence of a pillar (24.2%), FCE (20.0%) and atrophy (7.4%) were associated with poor BCVA (p<0.05). Gass lesion type 1 eyes were correlated with good BCVA (LogMAR <0.4) whereas type 5 eyes had poor BCVA (LogMAR >0.4). Among 65 eyes with longitudinal data (mean follow-up 5.1 years), 7 eyes (10.8%) reverted from higher to lower Gass lesion type; of these, 4 eyes (57.1%) had CNV responsive to intravitreal anti-vascular endothelial growth factor treatment.

conclusionOCT-based structural features are readily identifiable in patients with BVMD and have prognostic importance due to their correlation with BCVA.

Indexed as

dystrophygeneticsmacularetina

Identifiers

PMID34993349
PMCPMC8655537
OpenAlexW4200334882

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.