Evidence map›Paper›PMID 34993346›Full record

ReviewOpen medicine (Warsaw, Poland)2022

Hearing loss and brain disorders: A review of multiple pathologies.

Oluwafemi Gabriel Oluwole, Kili James, Abdoulaye Yalcouye, Ambroise Wonkam

Open access · goldAbstract readReview
In one paragraph

Review in Open medicine (Warsaw, Poland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
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  3. The identification of novel missense variant inOpen medicine (Warsaw, Poland) · 2025
    Article
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  5. Article
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  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Oluwafemi Gabriel OluwoleDivision of Human Genetics, Faculty of Health Sciences, University of Cape Town, 3.14 Wernher & Beit North Building, P.O Box 7925, Cape Town, South Africa.
Kili JamesDivision of Human Genetics, Faculty of Health Sciences, University of Cape Town, 3.14 Wernher & Beit North Building, P.O Box 7925, Cape Town, South Africa.
Abdoulaye YalcouyeDivision of Human Genetics, Faculty of Health Sciences, University of Cape Town, 3.14 Wernher & Beit North Building, P.O Box 7925, Cape Town, South Africa.
Ambroise WonkamDivision of Human Genetics, Faculty of Health Sciences, University of Cape Town, 3.14 Wernher & Beit North Building, P.O Box 7925, Cape Town, South Africa.
University of Cape Town · ZA

Funding

Hearing Impairment Genetics Studies in Africa (HI-GENES Africa)U01HG009716 · NHGRI · UNIVERSITY OF CAPE TOWN · PI WONKAM, AMBROISE · 2017 to 2021
$1.2M
NHGRI NIH HHS U01 HG009716Wellcome Trust
6 · The paper itself

Abstract

Several causative factors are associated with hearing loss (HL) and brain disorders. However, there are many unidentified disease modifiers in these conditions. Our study summarised the most common brain disorders associated with HL and highlighted mechanisms of pathologies. We searched the literature for published articles on HL and brain disorders. Alzheimer's disease/dementia, Parkinson's disease, cognitive impairment, autism spectrum disorder, ataxia, epilepsy, stroke, and hypoxic-ischaemic encephalopathy majorly co-interact with HL. The estimated incidence rate was 113 per 10,000 person-years. Genetic, epigenetic, early life/neonatal stress, hypoxia, inflammation, nitric oxide infiltration, endoplasmic reticulum stress, and excess glutamate were the distinguished modifiers identified. Various mechanisms like adhesion molecules, transport proteins, hair cell apoptosis, and neurodegeneration have been implicated in these conditions and are serving as potential targets for therapies. To improve the quality of life of patients, these understandings will improve clinical diagnoses and management of HL and brain disorders.

Indexed as

brain disorderscorrelated risk factorshearing losspathology

Identifiers

PMID34993346
PMCPMC8678477
OpenAlexW4200249024

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.