ArticleFrontiers in bioengineering and biotechnology2021
A Facile Method to Synthesize 3D Pomegranate-like Polydopamine Microspheres.
Article in Frontiers in bioengineering and biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 12 citations in OpenAlex.
- TGF-β1/BSA coating modulates multi-phasic scaffolds for osteochondral tissue regeneration.Materials today. Bio · 2025Article
- Polydopamine-based Surface Modifications for Tissue Engineering and Biosensing: From Understanding Chemistry to Diverse Applications.JOM (Warrendale, Pa. : 1989) · 2025Article
- Review
- Mussel-inspired polydopamine decorated alginate dialdehyde-gelatin 3D printed scaffolds for bone tissue engineering application.Frontiers in bioengineering and biotechnology · 2022Article
- The effects of process parameters on polydopamine coatings employed in tissue engineering applications.Frontiers in bioengineering and biotechnology · 2022Review
- A critical review on polydopamine surface-modified scaffolds in musculoskeletal regeneration.Frontiers in bioengineering and biotechnology · 2022Review
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nanospheres have found versatile applications in the biomedical field; however, their possible harmful effects on immune and inflammatory systems are also a crucial concern. Inspired by a pomegranate structure, we demonstrated a novel structure for the nanostructured microspheres to overcome the drawbacks of nanospheres without compromising their merits. In this study, 3D pomegranate-like polydopamine microspheres (PDAMS) were synthesized by self-oxidative polymerization of dopamine hydrochloride. Herein, controlling the pH during polymerization led to synthesizing homogeneous agglomerated nano-sized spheres (400-2000 nm) and finally forming tunable and monodisperse micron-sized particles (21 µm) with uniform spherical shape porous microstructure. PDAMS interaction with the potential targets, Bone morphogenetic protein-2 (BMP2), Decorin, and Matrilin-1, was investigated via molecular calculations. Theoretical energy analysis revealed that PDAMS interaction with BMP2, Decorin, and Matrilin-1 is spontaneous, so that a protein layer formation on the PDAMS surface suggests application in bone and cartilage repair. It was also observed that PDAMS presented
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Registered trials
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