Evidence map›Paper›PMID 34993082›Full record

ArticleQuantitative imaging in medicine and surgery2022

Ascending thoracic aortic aneurysm growth is minimal at sizes that do not meet criteria for surgical repair.

Arushi Gulati, Joseph Leach, Zhongjie Wang, Yue Xuan, Michael D Hope, David A Saloner, Liang Ge, Elaine E Tseng

Open access · diamondAbstract read
In one paragraph

Article in Quantitative imaging in medicine and surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Growth rates in non-syndromic aneurysms of the ascending aorta: a systematic review.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2024
    Review
  5. Review
  6. Ascending thoracic aortic aneurysm elongation occurs in parallel with dilatation in a nonsurgical population.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Arushi Gulati *Division of Adult Cardiothoracic Surgery, Department of Surgery, University of California San Francisco Medical Center and San Francisco VA Medical Center, San Francisco, CA, USA.
Joseph Leach *Department of Radiology, University of California San Francisco Medical Center and San Francisco VA Medical Center, San Francisco, CA, USA.
Zhongjie WangDivision of Adult Cardiothoracic Surgery, Department of Surgery, University of California San Francisco Medical Center and San Francisco VA Medical Center, San Francisco, CA, USA.
Yue XuanDepartment of Radiology, University of California San Francisco Medical Center and San Francisco VA Medical Center, San Francisco, CA, USA.
Michael D HopeDivision of Adult Cardiothoracic Surgery, Department of Surgery, University of California San Francisco Medical Center and San Francisco VA Medical Center, San Francisco, CA, USA.
David A SalonerDepartment of Radiology, University of California San Francisco Medical Center and San Francisco VA Medical Center, San Francisco, CA, USA.
Liang GeDivision of Adult Cardiothoracic Surgery, Department of Surgery, University of California San Francisco Medical Center and San Francisco VA Medical Center, San Francisco, CA, USA.
Elaine E TsengDivision of Adult Cardiothoracic Surgery, Department of Surgery, University of California San Francisco Medical Center and San Francisco VA Medical Center, San Francisco, CA, USA.
University of California San Francisco Medical Center · USSan Francisco VA Medical Center · US

Funding

Biomechanical Understanding of Ascending Thoracic Aortic AneurysmsR01HL119857 · NHLBI · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI GE, LIANG, TSENG, ELAINE EVELINA · 2015 to 2018
$1.5M
Hemodynamics of thrombosis after transcatheter aortic valve-in-valve implantationK25HL150408 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI XUAN, YUE · 2020 to 2022
$528k
NHLBI NIH HHS K25 HL150408NHLBI NIH HHS R01 HL119857
6 · The paper itself

Abstract

backgroundHistoric studies of nonsyndromic ascending thoracic aortic aneurysms (aTAAs) reported that the typical aTAA growth rate was approximately 0.6 mm/year, but data were limited due to relatively few studies using computed tomography (CT) imaging. Our purpose was to reevaluate the annual growth rate of nonsyndromic aTAAs that do not meet criteria for surgical repair in veterans in the contemporary era, using modern CT imaging suitable for highly accurate and reproducible aneurysm measurement.

methodsNonsurgical patients (diameter <5.5 cm) undergoing aneurysm surveillance at a Veterans Affairs Medical Center with repeat CT imaging performed 3 to 5 years apart were identified. Maximum diameter was determined by a single radiologist using multiplanar reformat-based measurements. Average rate of aneurysm growth was evaluated based on longest available follow-up.

resultsSixty-seven patients were included. Average follow-up time was 4.06±0.83 years. Patients were exclusively male, with average age of 68.1±6.0 years, and the majority had a history of smoking (n=52, 78%), hypertension (n=52, 78%), and dyslipidemia (n=48, 72%). Average baseline aneurysm diameter was 44.0±3.2 mm and average growth rate was 0.11±0.31 mm/year, with no difference in growth rate between patients with initial diameter ≤45

conclusionsIn this veteran population, most patients did not experience significant annual aneurysm growth over up to 5 years of follow-up, regardless of initial diameter. Thus, in the modern era, aTAAs may not grow as quickly as previously described, which will be important in determining appropriate intervals for aneurysm surveillance based upon risk-benefit ratio.

Indexed as

Aortic aneurysmsdiametergrowthtype A dissection

Identifiers

PMID34993082
PMCPMC8666776
OpenAlexW3181300849

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.