Severe Symptomatic Hypercalcemia in a Patient With Familial Hypocalciuric Hypercalcemia.

Roshini Kurian, Gagan Madegowda Chandrashekar, Mc Anto Antony, Lakshya Chandra, Ravi Kant

Open access · diamondAbstract readCase Reports

In one paragraph

Article in Cureus, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.1field-weighted citation impact, top 48% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

A Novel MissenseAACE clinical case reports
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Roshini KurianChemical Pathology, University Hospitals of Leicester, National Health Service Trust, Leicester, GBR.

Gagan Madegowda ChandrashekarGastroenterology, University Hospital of North Durham, Durham, GBR.

Mc Anto AntonyEndocrinology, Diabetes and Metabolism, Medical University of South Carolina, Anderson, USA.

Lakshya ChandraInternal Medicine, Bon Secour St. Francis Hospital, Greenville, USA.

Ravi KantEndocrinology, Diabetes and Metabolism, Medical University of South Carolina, Anderson, USA.

University Hospital of North Durham · GBAnderson University - South Carolina · USBon Secours Hospital · USUniversity Hospitals of Leicester NHS Trust · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

One of the less common causes of hypercalcemia is familial hypocalciuric hypercalcemia (FHH). It is an autosomal-dominant genetic condition, which presents asymptomatically in most patients while some may have mild symptoms. The serum calcium levels are mildly elevated with mild elevation in parathyroid hormone, which rarely requires management with pharmacologic agents. We present an unusual case report of a 76-year-old woman, confirmed to have FHH type 1 mutation, presented with symptomatic hypercalcemia probably set off by metabolic stresses of her age and needing intensive treatment with intravenous bisphosphonates, calcitonin and cinacalcet.

Indexed as

casr mutationcinacalcetcorrected serum calciumfamilial hypocalciuric hypercalcemiaurine calciumzolendronic acid

Identifiers

PMID34993031

DOI10.7759/cureus.20057

PMCPMC8720036

OpenAlexW3214789851

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.